Search by BoMiProt ID - Bomi8320

Primary Information

BoMiProt ID Bomi8320
Protein Name Protein associated with UVRAG as autophagy enhancer/ Pacer/Protein Rubicon-like
Organism Bos taurus
Uniprot IDA7E316
Milk FractionWhey
Ref Sequence ID NP_001095511.1
Aminoacid Length 663
Molecular Weight 73604
FASTA Sequence Download
Gene Name RUBCNL
Gene ID 517231
Protein Existence Status reviewed

Secondary Information

Protein Function Regulator of autophagy that promotes autophagosome maturation by facilitating the biogenesis of phosphatidylinositol 3-phosphate (PtdIns3P) in late steps of autophagy. Acts by antagonizing RUBCN, thereby stimulating phosphatidylinositol 3-kinase activity of the PI3K/PI3KC3 complex.
PTMs Acetylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions 1-132, 148-180
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs Acetylated by KAT5/TIP60 under autophagy induction, promoting autophagosome maturation and lipid metabolism. Lys-484 and Lys-574 constitute the key sites for tuning function in autophagy.
Bibliography Cheng, X., Ma, X., Ding, X., Li, L., Jiang, X., Shen, Z., Chen, S., Liu, W., Gong, W., & Sun, Q. (2017). Pacer Mediates the Function of Class III PI3K and HOPS Complexes in Autophagosome Maturation by Engaging Stx17. Molecular cell, 65(6), 1029–1043.e5.