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Primary Information | |
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| BoMiProt ID | Bomi8307 |
| Protein Name | Proteasome subunit beta type-6 |
| Organism | Bos taurus |
| Uniprot ID | Q3MHN0 |
| Milk Fraction | whey |
| Ref Sequence ID | NP_001029541.1 |
| Aminoacid Length | 239 |
| Molecular Weight | 25542 |
| FASTA Sequence | Download |
| Gene Name | PSMB6 |
| Gene ID | 510069 |
| Protein Existence Status | reviewed |
Secondary Information | |
| Protein Function | mediates the decay of m6A-containing IL11 and SERPINE2 mRNAs,mediators of cancer-promoting inflammation and reprogramming of the tumor vasculature.suppresses ERK/MAPK signaling by destabilizing EGFR . |
| PTMs | Acetylation, Phosphorylation |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | >sp|Q3MHN0|PSB6_BOVIN Proteasome subunit beta type-6 OS=Bos taurus OX=9913 GN=PSMB6 PE=1 SV=1 MAATLVAARGTRPAPAWGPEAIAPDWENREVSTGTTIMAVQFDGGVVLGADSRTTTGSYI ANRVTDKLT*69PIHDRIFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKEM CYRYREDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQPFAIGGSGSSYIYGYVDATYREG MTKEECLQFTANALALAMERDGSSGGVIRLAAIAEPGVERQVLLGDQIPKFTIATLPPL |
| SCOP | Class : Alpha and beta proteins (a+b) Fold : Type II GAT domain-like Superfamily : Class II glutamine amidotransferases Family : Proteasome subunits Domain Name : 1IRU H:1-202 |
| CATH | Matched CATH superfamily 3.60.20.10 |
| Predicted Disorder Regions | (13-29) |
| DisProt Annotation | |
| TM Helix Prediction | No TM helices |
| PDB ID | 1IRU, |
| Bibliography | Fang R, Chen X, Zhang S, Shi H, Ye Y, Shi H, Zou Z, Li P, Guo Q, Ma L, He C, Huang S. EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma. Nat Commun. 2021 Jan 8;12(1):177. doi: 10.1038/s41467-020-20379-7. PMID: 33420027; PMCID: PMC7794382. |