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Primary Information | |
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| BoMiProt ID | Bomi8301 |
| Protein Name | Proteasome subunit alpha type-2 |
| Organism | Bos taurus |
| Uniprot ID | Q3T0Y5 |
| Milk Fraction | Whey |
| Ref Sequence ID | NP_001029834.1 |
| Aminoacid Length | 234 |
| Molecular Weight | 25899 |
| FASTA Sequence | Download |
| Gene Name | PSMA2 |
| Gene ID | 539141 |
| Protein Existence Status | reviewed |
Secondary Information | |
| Protein Function | Proteasome subunit alpha type-2 (PSMA2) is a cellular protein highly expressed in IAV-infected human lung epithelial A549 cells.Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. |
| Biochemical Properties | PSMA2 is part of the 20S proteasome complex that degrades or recycles defective proteins and involves proteolytic modification of many cellular regulatory proteins. |
| PTMs | N6-Acetylation at Lys,Phosphorylation at Ser and Tyr |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | >sp|Q3T0Y5|PSA2_BOVIN Proteasome subunit alpha type-2 OS=Bos taurus OX=9913 GN=PSMA2 PE=1 SV=3 MAERGY*6S*7FSLTTFS*14PS*16GKLVQIEY*24ALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDER SVHKVEPITKHIGLVY*76SGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQE Y*121TQSGGVRPFGVSLLICGWNEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNE DLELEDAIHTAILTLKESFEGQMTEDNIEVGICNEAGFRRLTPTEVKDYLAAIA |
| SCOP | Class : Alpha and beta proteins (a+b) Fold : Type II GAT domain-like Superfamily : Class II glutamine amidotransferases Family : Proteasome subunits Domain Name : 1IRU B:1-233 |
| CATH | Matched CATH superfamily 3.60.20.10 |
| Predicted Disorder Regions | NA |
| DisProt Annotation | |
| TM Helix Prediction | no TM helices |
| Significance of PTMs | Phosphorylated on tyrosine residues; which may be important for nuclear import. |
| PDB ID | 1IRU, 7DR6, 7DR7, 7DRW, |
| Additional Comments | PSMA2 knockdown (KD) in A549 cells caused a significant reduction in extracellular progeny IAV(Influenza A virus ), but intracellular viral protein translation and viral RNA transcription were not affected. This indicates PSMA2 is a critical host factor for IAV maturation. |
| Bibliography | Rashid MU, Gao A, Coombs KM. Influenza A virus uses PSMA2 for downregulation of NRF2-mediated oxidative stress response. J Virol. 2022 Jan 12:jvi0199021. doi: 10.1128/jvi.01990-21. Epub ahead of print. PMID: 35019712. |