Search by BoMiProt ID - Bomi8301

Primary Information

BoMiProt ID Bomi8301
Protein Name Proteasome subunit alpha type-2
Organism Bos taurus
Uniprot IDQ3T0Y5
Milk FractionWhey
Ref Sequence ID NP_001029834.1
Aminoacid Length 234
Molecular Weight 25899
FASTA Sequence Download
Gene Name PSMA2
Gene ID 539141
Protein Existence Status reviewed

Secondary Information

Protein Function Proteasome subunit alpha type-2 (PSMA2) is a cellular protein highly expressed in IAV-infected human lung epithelial A549 cells.Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. 
Biochemical Properties PSMA2 is part of the 20S proteasome complex that degrades or recycles defective proteins and involves proteolytic modification of many cellular regulatory proteins. 
PTMs N6-Acetylation at Lys,Phosphorylation at Ser and Tyr
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
SCOP Class : Alpha and beta proteins (a+b)
Fold : Type II GAT domain-like
Superfamily : Class II glutamine amidotransferases
Family : Proteasome subunits
Domain Name : 1IRU B:1-233

CATH Matched CATH superfamily
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction no TM helices
Significance of PTMs Phosphorylated on tyrosine residues; which may be important for nuclear import.
PDB ID 1IRU, 7DR6, 7DR7, 7DRW,
Additional Comments  PSMA2 knockdown (KD) in A549 cells caused a significant reduction in extracellular progeny IAV(Influenza A virus ), but intracellular viral protein translation and viral RNA transcription were not affected. This indicates PSMA2 is a critical host factor for IAV maturation. 
Bibliography Rashid MU, Gao A, Coombs KM. Influenza A virus uses PSMA2 for downregulation of NRF2-mediated oxidative stress response. J Virol. 2022 Jan 12:jvi0199021. doi: 10.1128/jvi.01990-21. Epub ahead of print. PMID: 35019712.