Primary Information |
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| BoMiProt ID | Bomi8284 |
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| Protein Name | Prostacyclin receptor/Prostaglandin I2 receptor
PGI receptor/PGI2 receptor/Prostanoid IP receptor |
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| Organism | Bos taurus |
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| Uniprot ID | P79393 |
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| Milk Fraction | Whey,MFGM |
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| Aminoacid Length | 385 |
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| Molecular Weight | 41247 |
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| FASTA Sequence |
Download |
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| Gene Name | PTGIR |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Receptor for prostacyclin (prostaglandin I2 or PGI2).G-protein coupled receptor (GPCR).prevention of atherothrombosis.Prostacyclin is a potent vasodilator, antithrombotic, and antiplatelet agent that mediates it effects through a membrane-associated receptor termed the IP. |
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| PTMs | Disulfide bond addition, Glycosylation on Asn, Methylation, Prenylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|P79393|PI2R_BOVIN Prostacyclin receptor OS=Bos taurus OX=9913 GN=PTGIR PE=3 SV=1
MADSCRN*7LTYVRDSVGPATSTLMFVAGVVGNGLALGILGARRHSRPSAFAVLVTGLGVTD
LLGTCFLSPAVFAAYARNSSLLGLARGRPALCDAFAFAMTFFGLASTLILFAMAVERCLA
LSHPYLYAQLDGPRRARLALPAIYAFCTIFCSLPFLGLGQHQQYCPGSWCFIRMRSAEPG
GCAFLLAYASLVALLVAAIVLCNGSVTLSLCRMYRQQRRHQARCPRPRAGEDEVDHLILL
ALMTGIMAVCSLPLTPQIRGFTQAIAPDSSEMGDLLAFRFNAFNPILDPWVFILFRKSVF
QRLKLWFCCLYSRPAQGDSRTSLSQSASGRKDSSAPPALEGKKGNWVPLSAWGEGQGGPL
PAVQLPTSTVGTPSKAGSEAACSLC |
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| Predicted Disorder Regions | 1 disordered segment; (319-381) |
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| DisProt Annotation | |
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| TM Helix Prediction | 6TMHs; (15-37), (50-72) ,(94-116) ,(136-158), (188-210) & (237-255) |
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| Bibliography | Smyth EM, FitzGerald GA. Human prostacyclin receptor. Vitam Horm. 2002;65:149-65. doi: 10.1016/s0083-6729(02)65063-0. PMID: 12481546. |
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