Primary Information
BoMiProt ID	Bomi8239
Protein Name	Profilin-2
Organism	Bos taurus
Uniprot ID	Q09430
Milk Fraction	Exosomes
Ref Sequence ID	NP_001121669.1
Aminoacid Length	140
Molecular Weight	15032
FASTA Sequence	Download
Gene Name	PFN2
Gene ID	539034
Protein Existence Status	Reviewed
Secondary Information
Presence in other biological fluids/tissue/cells	occipital lobe
Protein Function	PFN2 promotes the proliferation, migration and invasion of TNBC cells by regulating epithelial-to-mesenchymal transition.
PTMs	N-acetylation at Alanine
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	NA
Predicted Disorder Regions	NA
DisProt Annotation
TM Helix Prediction	No TM helices
Additional Comments	PFN2 increased, whereas its knockdown (KD) decreased the proliferation, migration, and invasion of SCLC cell H446.
Bibliography	1.Cao Q, Liu Y, Wu Y, Hu C, Sun L, Wang J, Li C, Guo M, Liu X, Lv J, Huo X, Yue J, Du X, Chen Z. Profilin 2 promotes growth, metastasis, and angiogenesis of small cell lung cancer through cancer-derived exosomes. Aging (Albany NY). 2020 Nov 21;12(24):25981-25999. doi: 10.18632/aging.202213. Epub 2020 Nov 21. PMID: 33234737; PMCID: PMC7803489. 2.Ling Y, Cao Q, Liu Y, Zhao J, Zhao Y, Li K, Chen Z, Du X, Huo X, Kang H, Chen Z. Profilin 2 (PFN2) promotes the proliferation, migration, invasion and epithelial-to-mesenchymal transition of triple negative breast cancer cells. Breast Cancer. 2021 Mar;28(2):368-378. doi: 10.1007/s12282-020-01169-x. Epub 2020 Oct 12. PMID: 33047272.