Primary Information |
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| BoMiProt ID | Bomi8231 |
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| Protein Name | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 |
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| Organism | Bos taurus |
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| Uniprot ID | O77588 |
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| Milk Fraction | Whey,Casein |
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| Ref Sequence ID | NP_776573.1 |
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| Aminoacid Length | 726 |
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| Molecular Weight | 83487 |
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| FASTA Sequence |
Download |
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| Gene Name | PLOD1 |
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| Gene ID | 281409 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Protein Function | collagen-related lysyl hydroxylase take part in collagen fibril formation.PLOD1 can hydroxylate lysyl residues during peptide bond formation and consequently acts as an important enhancer of collagen fibril deposition and cross-link stabilization. |
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| Biochemical Properties | Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens.Protein has several cofactor binding sites for Fe2+ and Ascorbate. 2-oxoglutarate + L-lysyl-[collagen] + O2 = (5R)-5-hydroxy-L-lysyl-[collagen] + CO2 + succinate |
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| PTMs | Glycosylation on Asn |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|O77588|PLOD1_BOVIN Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 OS=Bos taurus OX=9913 GN=PLOD1 PE=2 SV=2
MRLLLLLAPLGWLLLAETKGDAKPEDNLLVLTVATKETEGFRRFKRSAQFFNYKIQALGL
GEDWPGEAMLAGGGLKVRLLKKALEKHADKENLVILFTDSYDVVFASGPRELLKKFRQAR
SQVVFSAEELIYPDRRLEAKYPVVSDGKRFLGSGGFIGYAPNLSKLVAEWEGQDSDSDQL
FYTKIFLDPEKREQIN*196ITLDHRCRIFQNLDGALDEVVLKFEMGQVRARNLAYDTLPVLIH
GNGPTKLQLNYLGNYIPRFWTFETGCAVCDEGLRSLKGIGDEALPAVLVGVFIEQPTPFL
SLFFQRLLRLHYPQKRLRLFIHNHEQHHKAQVEQFLAEHGDEYQSVKLVGPEVRVANADA
RNMGADLCRQDRGCTYYFSVDADVALTEPKTLRLLIEQNKNVIAPLMTRHGRLWSNFWGA
LSADGYYARSEDYVDIVQGRRVGVWNVPYISNIYLIKGSALRAELQETDLFHHSKLDPDM
AFCANIRQQDVFMFLTNRHSFGHLLSLDSYQTTHLHNDLWEVFSNPEDWKEKYIHEN*537YTK
ALAGKMVEMPCPDVYWFPIFTETACDELVEEMEHYGQWSLGDNKDNRIQGGYENVPTIDI
HMNQINFEREWHKFLVEYIAPMTEKLYPGYYTRAQFDLAFVVRYKPDEQPSLVPHHDAST
FTINIALNRVGVDYEGGGCRFLRYN*685CSIRAPRKGWTLMHPGRLTHYHEGLPTTKGTRYIA
VSFVDP
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | PLOD1 is dysregulated in bladder cancer lesions and that silencing PLOD1 can significantly impair proliferation, migration, and invasion in bladder cancer cells.High expression levels of PLODs have been observed in various cancer types, and have been found to regulate tumor growth, invasion and metastasis, as well as radio-resistance. |
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| Bibliography | 1.Yuan B, Xu Y, Zheng S. PLOD1 acts as a tumor promoter in glioma via activation of the HSF1 signaling pathway. Mol Cell Biochem. 2022 Feb;477(2):549-557. doi: 10.1007/s11010-021-04289-w. Epub 2021 Nov 29. PMID: 34845571. |
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