Primary Information
BoMiProt ID	Bomi8224
Protein Name	Probable tubulin polyglutamylase TTLL1/Tubulin polyglutamylase complex subunit 3/Tubulin--tyrosine ligase-like protein 1
Organism	Bos taurus
Uniprot ID	Q0VC71
Milk Fraction	Whey
Ref Sequence ID	NP_001069639.1
Aminoacid Length	423
Molecular Weight	49030
FASTA Sequence	Download
Gene Name	TTLL1
Gene ID	539530
Protein Existence Status	reviewed
Secondary Information
Protein Function	TTLL1 complex may be involved in tubulin substrate recognition, regulation of enzymatic activity, or subcellular localization
Biochemical Properties	TTLL1 is a member of a large family of proteins with a TTL homology domain, whose members could catalyze ligations of diverse amino acids to tubulins or other substrates.The amino acid sequence of TTLL1 (PGs3) contains three conserved motifs that correspond to the adenosine triphosphate (ATP)/Mg2þ-binding site typical of enzymes with a carboxylateamine/thiol ligase activity, such as glutathione synthetase.
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	NA
Predicted Disorder Regions	NA
DisProt Annotation
TM Helix Prediction	No TM helices
Additional Comments	TTLL1 and TTL are members of a large family of conserved eukaryotic proteins with a TTL homology domain, which raises the possibility that other members of this family are also involved in polyglutamylation or other types of posttranslational amino acid ligations
Bibliography	1.Janke C, Rogowski K, Wloga D, Regnard C, Kajava AV, Strub JM, Temurak N, van Dijk J, Boucher D, van Dorsselaer A, Suryavanshi S, Gaertig J, Eddé B. Tubulin polyglutamylase enzymes are members of the TTL domain protein family. Science. 2005 Jun 17;308(5729):1758-62. doi: 10.1126/science.1113010. Epub 2005 May 12. PMID: 15890843. 2.C. Regnard et al., J. Cell Sci. 116, 4181 (2003).