Primary Information |
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| BoMiProt ID | Bomi8216 |
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| Protein Name | Probable cationic amino acid transporter/Solute carrier family 7 member 14 |
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| Organism | Bos taurus |
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| Uniprot ID | A0JNI9 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001071460.1 |
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| Aminoacid Length | 771 |
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| Molecular Weight | 84188 |
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| FASTA Sequence |
Download |
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| Gene Name | SLC7A14 |
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| Gene ID | 533046 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | CAT1 is likely to be the most relevant with regard to quantitative transport of L-arginine as it exhibits a high transport capacity and shows an almost ubiquitous tissue distribution (with the exception of the liver). |
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| Significance in milk | Important for cell division, the healing of wounds, removing ammonia from the body, immune functions, and the release of growth hormone. |
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| PTMs | N-Linked Glycosylation,Phosphorylation ar Ser |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A0JNI9|S7A14_BOVIN Probable cationic amino acid transporter OS=Bos taurus OX=9913 GN=SLC7A14 PE=2 SV=1
MSGFLTSLDPRRVQWGAAWYAMHSRILRTKPVESMLEGTGATTAHGTKLAQVLTTMDLIS
LGVGSCVGTGMYVVSGLVAKEMAGPGVIVSFIIAAVASILSGVCYAEFGVRVPKTTGSAY
TYSYVTVGEFVAFFIGWNLILEYLIGTAAGASALSSMFDSLANHTISRWMVDSVGTLNGL
GKGEQSYPDLLALVIAIIVTIIVALGVKNSVGFNNVLNVLNLAVWVFIMIAGFFFINGKY
WAEGQFLPYGWSGVLQGAATCFYAFIGFDIIATTGEEAKNPN*282SIPYAITASLVICLTAY
VSVSMILTLMVPYDTIDTESPLMEMFVARGFYAAKFVVAIGSVAGLTVSLLGSLFPMPRV
IYAMAGDGLLFRFLAHVSSYTETPVVACIVSGFLAALLSLLVSLRDLIEMMSIGTLLAYT
LVSVCVLLLRYQPESDIDGFVKFLSEEHTKKKEGILADCEKEVCS*465PVS*468EGEEFSGPATNT
CGAKNLPS*488LGDNEMLIGKSDKSTYNVNHPNYGTVDMTTGIEADESENIYLIKLKKLIGPR
YYTMRIQLGLPGKMDRPTAATGHTVTICVLLLFILMFVFCSFIIFGSDYISEQSWWAILL
VVLMVLLISALVFVILQQPENPKKLPYMAPCLPFVPAFAMLVNIYLMLKLSTITWIRFAV
WCFVGMLIYFGYGIWN*676STLEISAREEALHQSTYQRYDVDDPFSVEEGFSYATEGESQENW
GGPAEDKGFYYQQMSDTQPNTRTSSKAKSKSKHKQNS*757EALIANDELDYS*769PE
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| Predicted Disorder Regions | 37-41, 700-771 |
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| DisProt Annotation | |
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| TM Helix Prediction | 14TMHs; (58-76),(88-110),(130-152),(190-212),(219-237),(246-268),(289-311),(330-352),(385-403),(407-429),(563-585),(594-616),(629-647),(653-675) |
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| Additional Comments | In humans CAT2B is mainly expressed in immune cells such as macrophages and CAT2A primarily in the liver |
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| Bibliography | 1.Strobel J, Mieth M, Endress B, Auge D, König J, Fromm MF, Maas R. Interaction of the cardiovascular risk marker asymmetric dimethylarginine (ADMA) with the human cationic amino acid transporter 1 (CAT1). J Mol Cell Cardiol. 2012 Sep;53(3):392-400. doi: 10.1016/j.yjmcc.2012.06.002. Epub 2012 Jun 15. PMID: 22705145. |
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