Primary Information |
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| BoMiProt ID | Bomi8208 |
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| Protein Name | Pre-mRNA-splicing factor SLU7 |
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| Organism | Bos taurus |
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| Uniprot ID | Q3ZBE5 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001160089.1 |
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| Aminoacid Length | 586 |
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| Molecular Weight | 68203 |
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| FASTA Sequence |
Download |
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| Gene Name | SLU7 |
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| Gene ID | 512318 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | required for cleavage of the 3' splice site and exon ligation during splicing.SLU7 is only required when the interval between the branchpoint and the 3' splice site is greater than 7 nt.SLU7 is necessary for the correct expression of Pri-miR-17-92 to generate the miRNAs contained in this cluster. The expression of these miRNAs is necessary to inhibit oxidative stress, autophagy and apoptosis. |
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| PTMs | Acetylation, Isopeptide bond formation, Phosphorylation, Ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q3ZBE5|SLU7_BOVIN Pre-mRNA-splicing factor SLU7 OS=Bos taurus OX=9913 GN=SLU7 PE=2 SV=2
MSAAAVDAANAAPLSGSKEMSLEEPKKMTREDWRKKKELEEQRKLGNAPAEVDEEGKDIN
PHIPQYISSVPWYIDPSKRPTLKHQRPQPEKQKQYSSSGEWYKRGVKENSITTKYRKGAC
ENCGAMTHKKKDCFERPRRVGAKFTGTNIAPDEHVQPQLMFDYDGKRDRWNGYNPEEHMK
IVEEYAKVDLAKRTLKAQKLQEELASGKLVEQANS*215PKHQWGEEEPNS*227QTEKDHNS*235EDEDE
DKYADDIDMPGQNFDSKRRITVRNLRIREDIAKYLRNLDPNSAYYDPKTRAMRENPYANA
GKNPDEVSYAGDNFVRYTGDTISMAQTQLFAWEAYDKGSEVHLQADPTKLELLYKSFKVK
KEDFKEQQKESILEKYGGQEHLDAPPAELLLAQTEDYVEYSRHGTVIKGQERAVACSKYE
EDVKINNHTHIWGSYWKEGRWGYKCCHSFFKYSYCTGEAGKEIANSEECIINDATGEESV
KKPQTLMEIHQEKLKEEKKKKKKKKRKHRKSSSESDDEEKKHEKLKKALNAEEARLLHVK
EIMQIDERKRPYNSIYETREPTEEEMEAYRMKRQRPDDPMASFLGQ
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| Predicted Disorder Regions | 9-58, 71-103, 120-146, 164-174, 206-246, 286-306, 471-521 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | 1.Urtasun, R., Elizalde, M., Azkona, M. et al. Splicing regulator SLU7 preserves survival of hepatocellular carcinoma cells and other solid tumors via oncogenic miR-17-92 cluster expression. Oncogene 35, 4719–4729 (2016). https://doi.org/10.1038/onc.2015.517 2.Brys A, Schwer B. Requirement for SLU7 in yeast pre-mRNA splicing is dictated by the distance between the branchpoint and the 3' splice site. RNA. 1996 Jul;2(7):707-17. PMID: 8756413; PMCID: PMC1369409. |
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