Primary Information |
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| BoMiProt ID | Bomi8207 |
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| Protein Name | Pre-mRNA-splicing factor RBM22/RNA-binding motif protein 22 |
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| Organism | Bos taurus |
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| Uniprot ID | Q3B7L8 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001032907.1 |
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| Aminoacid Length | 420 |
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| Molecular Weight | 46930 |
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| FASTA Sequence |
Download |
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| Gene Name | RBM22 |
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| Gene ID | 512330 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Pre-spliceosome assembly.interaction with U2–U6 snRNA and its stabilization during spliceosome formation. |
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| Biochemical Properties | RNA-binding motif protein with a conserved RNA-binding domain, a zinc finger domain C-x8-C-x5-C-x3-H, and a C-terminus that is unusually rich in the amino acids Gly and Pro, including sequences of tetraprolines. |
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| PTMs | Acetylation and phosphorylation on Ser |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q3B7L8|RBM22_BOVIN Pre-mRNA-splicing factor RBM22 OS=Bos taurus OX=9913 GN=RBM22 PE=2 SV=1
MATS*4LGSNTYNRQNWEDADFPILCQTCLGENPYIRMTKEKYGKECKICARPFTVFRWCPG
VRMRFKKTEVCQTCSKLKNVCQTCLLDLEYGLPIQVRDAGLS*102FKDDMPKSDVNKEYYTQN
MEREISNSDGTRPVGMLGKATSTSDMLLKLARTTPYYKRNRPHICSFWVKGECKRGEECP
YRHEKPTDPDDPLADQNIKDRYYGINDPVADKLLKRASTMPRLDPPEDKTITTLYVGGLG
DTITETDLRNHFYQFGEIRTITVVQRQQCAFIQFATRQAAEVAAEKSFNKFIVNGRRLNV
KWGRSQAARGKEKEKDGTTDSGIKLEPVPGLPGALPPPPAAEEEASANYFNLPPSGPPAV
VNIALPPPPGIAPPPPPGFGPHMFHPMGPPPPFMRAPGPIHYPSQDPQRMGAHAGKHSSP
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | 1.Ciavarella J, Perea W, Greenbaum NL. Topology of the U12-U6atac snRNA Complex of the Minor Spliceosome and Binding by NTC-Related Protein RBM22. ACS Omega. 2020 Sep 4;5(37):23549-23558. doi: 10.1021/acsomega.0c01674. PMID: 32984674; PMCID: PMC7512442.2.He F, Wang CT, Gou LT. RNA-binding motif protein RBM22 is required for normal development of zebrafish embryos. Genet Mol Res. 2009 Dec 8;8(4):1466-73. doi: 10.4238/vol8-4gmr683. PMID: 20013661. |
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