Primary Information |
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| BoMiProt ID | Bomi8177 |
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| Protein Name | POU domain, class 5, transcription factor 1/Octamer-binding protein 3/Octamer-binding transcription factor 3 |
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| Organism | Bos taurus |
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| Uniprot ID | O97552 |
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| Milk Fraction | Whey |
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| Aminoacid Length | 360 |
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| Molecular Weight | 38289 |
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| FASTA Sequence |
Download |
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| Gene Name | POU5F1/OCT3 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Bovine blastocyst formation.transcription factor and master regulator of cell pluripotency with indispensable roles in early embryo development and cell lineage specification. |
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| Biochemical Properties | binding to a specific octameric sequence motif (ATGCAAT) on enhancer and promoter regions of target genes through POU domain to activate and repress gene expression. |
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| PTMs | Isopeptide bond formation, Phosphorylation, Ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|O97552|PO5F1_BOVIN POU domain, class 5, transcription factor 1 OS=Bos taurus OX=9913 GN=POU5F1 PE=2 SV=1
MAGHLASDFAFSPPPGGGGDGPGGPEPGWVDPRTWMSFQGPPGGSGIGPGVVPGAEVWGL
PPCPPPYDLCGGMAYCAPQVGVGPVPPGGLETPQPEGEAGAGVESNSEGAS*111PDPCAAPAG
APKLDKEKLEPNPEESQDIKALQKDLEQFAKLLKQKRITLGYTQADVGLTLGVLFGKVFS
QTTICRFEALQLSFKNMCKLRPLLQKWVEEADNNENLQEICKAETLVQARKRKRT*235S*236IENR
VRGNLESMFLQCPKPTLQQISHIAQQLGLEKDVVRVWFCNRRQKGKRSS*289S*290DYSQREDFEA
AGSPFTGGPVSSPLAPGPHFGTPGYGGPHFTTLYSSVPFPEGEVFPSVSVTALGS*355PMHAN
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| Predicted Disorder Regions | 4 disordered segments; (4-52), (74-140), (287-294), (303-334) |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | Daigneault BW, Rajput S, Smith GW, Ross PJ. Embryonic POU5F1 is Required for Expanded Bovine Blastocyst Formation. Sci Rep. 2018 May 17;8(1):7753. doi: 10.1038/s41598-018-25964-x. PMID: 29773834; PMCID: PMC5958112. |
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