Primary Information |
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| BoMiProt ID | Bomi8173 |
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| Protein Name | Potassium voltage-gated channel subfamily KQT member 3/KQT-like 3/Potassium channel subunit alpha KvLQT3/Voltage-gated potassium channel subunit Kv7.3 |
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| Organism | Bos taurus |
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| Uniprot ID | P58126 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_776799.1 |
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| Aminoacid Length | 866 |
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| Molecular Weight | 95645 |
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| FASTA Sequence |
Download |
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| Gene Name | KCNQ3 |
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| Gene ID | 281884 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Associates with KCNQ2 or KCNQ5 to form a potassium channel |
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| PTMs | Phosphorylation,Ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | 1-51, 70-80, 488-496, 583-611, 660-662, 680-727, 763-768, 799-815, 832-866 |
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| DisProt Annotation | |
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| TM Helix Prediction | 5 TMHs; (121-143), (155-177), (197-215), (264-282), (331-353) |
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| Significance of PTMs | ubiquitinated by NEDD4L. Ubiquitination leads to protein degradation. |
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| Additional Comments | epilepsy is due to mutation of this gene. |
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| Bibliography | Rak SG, Drögemüller C, Leeb T, Quignon P, André C, Distl O. Assignment of the canine potassium voltage-gated channel, KQT-like subfamily, member 3 (KCNQ3) gene to CFA 13 by radiation hybrid mapping. Anim Genet. 2002 Aug;33(4):320-1. doi: 10.1046/j.1365-2052.2002.t01-6-00886.x. PMID: 12139519. |
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