Primary Information |
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| BoMiProt ID | Bomi8169 |
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| Protein Name | Potassium voltage-gated channel subfamily D member 1/Voltage-gated potassium channel subunit Kv4.1 |
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| Organism | Bos taurus |
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| Uniprot ID | Q52PG9 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001019724.1 |
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| Aminoacid Length | 648 |
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| Molecular Weight | 71378 |
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| FASTA Sequence |
Download |
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| Gene Name | KCND1 |
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| Gene ID | 518384 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Protein Function | voltage-activated A-type potassium ion channels which functions in the repolarization of membrane action potentials. Activity of voltage-gated potassium channels is important in a number of physiological processes, among them the regulation of neurotransmitter release, heart rate, insulin secretion, and smooth muscle contraction. [ |
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| Biochemical Properties | It contains 6 potential membrane-spanning hydrophobic segments, a pore domain with the K+ channel signature motif 'GYGD,' and intracellular N- and C-termini, but no N-glycosylation sites. |
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| PTMs | phosphorylation on Ser and N linked glycosylation on Asn |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q52PG9|KCND1_BOVIN Potassium voltage-gated channel subfamily D member 1 OS=Bos taurus OX=9913 GN=KCND1 PE=2 SV=1
MAAGVATWLPFARAAAVGWLPLAQQPLPPAPGVKASRGDEVLVVNVSGRRFETWKNTLDR
YPDTLLGSSEKEFFYNADSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAF
YGLVPELVGDCCLEEYRDRKKENAERLAEDEEAEQAGDGPTLPAGSSLRQRLWRAFENPH
TSTAALVFYYVTGFFIAVSVIANVVETIPCRSPTRRPPREQPCGDRFPLAFFCMDTACVL
IFTGEYLLRLFAAPSRCRFLRSVMSLIDVVAILPYYIGLFMPKNEDVSGAFVTLRVFRVF
RIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGTN*352KTN*355FTSIP
AAFWYTIVTMTTLGYGDMVPSTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQR
ADKRRAQQKVRLARIRLAKSGTTNAFLQYKQNGSLEDS*458GGGEEQALCVRNRSAFEQQHHH
LLHCLEKTTCHEFTDELTFSEALGAVSLGSRTSRSTSVSSQPVGAGSLLSSCCPRRAKRR
AIRLANSTASVSRGS*555MQELDTLAGLRRSPAPQSRSSLNAKPHDSLDLTCDSRDFVAAIIS
IPTPPANTPDESQPSSPGGGGGGASSTLRNSSLGTPCLLPETVKISSL
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| Predicted Disorder Regions | 31-33,155-164, 511-648 |
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| DisProt Annotation | |
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| TM Helix Prediction | 5TMHs; (183-205),(259-281), ( 326-348),( 361-383),(387-409) and (961-979) |
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| Bibliography | Isbrandt D, Leicher T, Waldschütz R, Zhu X, Luhmann U, Michel U, Sauter K, Pongs O. Gene structures and expression profiles of three human KCND (Kv4) potassium channels mediating A-type currents I(TO) and I(SA). Genomics. 2000 Mar 1;64(2):144-54. doi: 10.1006/geno.2000.6117. PMID: 10729221. |
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