Primary Information |
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| BoMiProt ID | Bomi8150 |
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| Protein Name | Polypyrimidine tract-binding protein 1 |
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| Organism | Bos taurus |
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| Uniprot ID | Q8WN55 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_776867.1 |
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| Aminoacid Length | 531 |
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| Molecular Weight | 57105 |
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| FASTA Sequence |
Download |
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| Gene Name | PTBP1 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | growth and differentiation of neuronal cells and activation of immune cells.Plays a role in pre-mRNA splicing.Activates exon skipping of its own pre-mRNA during muscle cell differentiation. promote the binding of U2 snRNP to pre-mRNA. |
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| PTMs | Acetylation on Met,Phosphorylation on Ser ,Thr and Tyr, Ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q8WN55|PTBP1_BOVIN Polypyrimidine tract-binding protein 1 OS=Bos taurus OX=9913 GN=PTBP1 PE=2 SV=1
MDGIVPDIAVGTKRGS*16DELFSACVTNGPFIMSGTSASTANGNDSKKFKGDSRSAGVPSRV
IHIRKLPGDVTEGEVISLGLPFGKVTNLLMLKGKNQAFIEMHTEEAANTMVNYYTSVTPV
LRGQPIY*127IQFSNHKELKT*138DSS*141PNQARAQAALQAVNSVQSGNLALAASAAAVDAGMAMAGQ
SPVLRIIVENLFYPVTLDVLHQIFSKFGTVLKIITFTKNNQFQALLQYADPVSAQHAKLS
LDGQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDYTRPDLPSGDSQPSLDQTMAAAFGLS
VPNVHGALAPLAIPSAAAAAAAAGRIAIPGLAGAGNS*433VLLVSNLNPERVTPQSLFILFGV
YGDVQRVKVLFNKKENALVQMADGSQAQLAMSHLNGHKLHGKPVRITLSKHQSVQLPREG
QEDQGLTKDYGNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSISEDDLKILFSSNGGI
VKGFKFFQKDRKMALIQMGSVEEAIQALIDLHNHDLGENHHLRVSFSKSTI
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| Predicted Disorder Regions | 4 disordered segments; (33-57), (136-148), (272-285), (399-407) |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | Zhu W, Zhou BL, Rong LJ, Ye L, Xu HJ, Zhou Y, Yan XJ, Liu WD, Zhu B, Wang L, Jiang XJ, Ren CP. Roles of PTBP1 in alternative splicing, glycolysis, and oncogensis. J Zhejiang Univ Sci B. 2020 Feb.;21(2):122-136. doi: 10.1631/jzus.B1900422. Epub 2020 Feb 5. PMID: 32115910; PMCID: PMC7076342. |
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