Primary Information |
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BoMiProt ID | Bomi8057 |
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Protein Name | Platelet-activating factor acetylhydrolase IB subunit beta/Lissencephaly-1 protein(
LIS-1)/PAF acetylhydrolase 45 kDa subunit/PAF-AH alpha |
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Organism | Bos taurus |
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Uniprot ID | P43033 |
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Milk Fraction | Whey |
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Ref Sequence ID | NP_777088.1 |
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Aminoacid Length | 410 |
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Molecular Weight | 46613 |
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FASTA Sequence |
Download |
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Gene Name | PAFAH1B1/LIS1/PAFAHA |
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Gene ID | 282513 |
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Protein Existence Status | reviewed |
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Secondary Information |
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Protein Function | Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase,an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in the PAF inactivation. essential regulator of dynein-mediated motility, as well as mitosis, nuclear positioning, and microtubule organization. |
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Biochemical Properties | beta subunit is imp for catalytic activity. |
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Significance in milk | related to fertility |
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PTMs | Acetylation and phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|P43033|LIS1_BOVIN Platelet-activating factor acetylhydrolase IB subunit beta OS=Bos taurus OX=9913 GN=PAFAH1B1 PE=1 SV=2
MVLSQRQRDELNRAIADYLRSNGYEAAYSVFKKEAELDMNEELDKKYAGLLEKKWTSVIR
LQKKVMELESKLNEAKEEFTSGGPLGQKRDPKEWIPRPPEKYALSGHRS*109PVTRVIFHPVF
SVMVSASEDATIKVWDYETGDFERTLKGHTDSVEDISFDHSGKLLASCSADMTIKLWDFQ
GFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMV
RPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSE
TKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDK
TLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR
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Predicted Disorder Regions | 79-86, 296-307 |
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DisProt Annotation | |
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TM Helix Prediction | No TM helices |
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Significance of PTMs | phosphorylated on serine residues by a kinase associated with microtubules,probably affecting its catalytic function. |
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Bibliography | Sapir T, Cahana A, Seger R, Nekhai S, Reiner O. LIS1 is a microtubule-associated phosphoprotein. Eur J Biochem. 1999 Oct 1;265(1):181-8. doi: 10.1046/j.1432-1327.1999.00711.x. PMID: 10491172. |