Primary Information |
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| BoMiProt ID | Bomi8056 |
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| Protein Name | Platelet endothelial cell adhesion molecule/CD_antigen: CD31/PECAM-1 |
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| Organism | Bos taurus |
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| Uniprot ID | P51866 |
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| Milk Fraction | Whey |
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| Aminoacid Length | 739 |
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| Molecular Weight | 82586 |
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| FASTA Sequence |
Download |
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| Gene Name | PECAM1 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | is a endothelial mechanosensing complex,role in in flow-mediated Gab1 tyrosine phosphorylation and endothelial NOS( nitric oxide (NO) synthase) signaling in endothelial cells.PECAM1 and CXCR4 together,activate the B-cell and NF-κB signaling pathways, leading to inflammatory cell infiltration. |
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| PTMs | Disulfide bond, Glycosylation, Lipidation, Palmitoylation, Phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|P51866|PECA1_BOVIN Platelet endothelial cell adhesion molecule OS=Bos taurus OX=9913 GN=PECAM1 PE=1 SV=1
MQLRWTQRGMMWLGALLTLLLCSSLKGQENSFTINSIHMQILPHSTVQNGEN*52LTLQCLVD
VSTTSRVKPLHQVLFYKDDVLLHN*84VSSRRNTESYLIPHVRVCDSGRYKCNVILNNKEKTT
PEYEVWVKGVSDPRVTLDKKEVIEGGVVVVN*151CSVPEEKAPVHFTIEKFELNIRGAKKKRE
KTSQNQNFVTLEFTVEEQDRTIRFQCQAKIFSGSNVESSRPIQSDLVTVRESFSNPKFHI
IPEGKVMEGDDLQVKCTVQVTHQAQSFPEIIIQKDREIVAHNSLSSEAVYSVMATTEHNG
N*301YTCKVEASRISKVSSVVVN*320VTELFSKPKLESSATHLDQGEDLNLLCSIPGAPPAN*356FTIQ
KGGMTVSQTQN*371FTKRVSEWDSGLYTCVAGVGRVFKRSNTVQITVCEMLSKPSIFHDSRSE
VIKGQTIEVSCQSVN*435GTAPIFYQLSN*446TSKPVAN*453QSVGSNKPAIFRVKPTKDVEYCCSADN
CHSHSKMFSEVLRVKVIAPVDEAQLVVLKGEVEPGEPIVFYCSVNEGSFPITYKFYKEKE
SKPFYQDTIN*550ATQIMWHKTTASKEYEGQYYCTASNRAN*578LSKHVIQSNTLTVRVYLPLEKG
LIAVVVIGVIIVTLVLGAKCYFLKKAKAKQMPVEMSRPAVPLLNSNNEKTLSDAGTEADR
HYGYNEDVGNHAMKPLNENKEPLTLDVEY*689TEVEVTSPEPHQGLGTKGTETETVY*714SEIRKA
DPDFVENRYS*730RTEGS*735LDGS
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| Predicted Disorder Regions | (629-684), (703-739) |
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| DisProt Annotation | |
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| TM Helix Prediction | 1TMH; (601-623) |
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| Bibliography | Xu S, Ha CH, Wang W, Xu X, Yin M, Jin FQ, Mastrangelo M, Koroleva M, Fujiwara K, Jin ZG. PECAM1 regulates flow-mediated Gab1 tyrosine phosphorylation and signaling. Cell Signal. 2016 Mar;28(3):117-124. doi: 10.1016/j.cellsig.2015.12.007. Epub 2015 Dec 17. PMID: 26706435; PMCID: PMC4724494. |
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