Primary Information |
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| BoMiProt ID | Bomi8035 |
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| Protein Name | Pinin |
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| Organism | Bos taurus |
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| Uniprot ID | P79122 |
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| Milk Fraction | Whey |
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| Aminoacid Length | 703 |
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| Molecular Weight | 79491 |
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| FASTA Sequence |
Download |
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| Gene Name | PNN |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | to pin intermediate filaments to the desmosome.participate the intermediate filament-desmosome complex formation. |
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| Biochemical Properties | contain heptad repeats which forms coiled-coil rod domains. Two glycine loop sequence segments are found on the C terminal of the heptad repeat region.Glycine loops are expected to be highly flexible, and may participate in interactions with neighboring glycine loops on the same or
adjacent proteins. |
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| PTMs | Acetylation, Isopeptide bond, Methylation, Phosphorylation, Ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|P79122|PININ_BOVIN Pinin OS=Bos taurus OX=9913 GN=PNN PE=2 SV=3
MAVAVRTLQEQLEKAKESLKNVDENIRKLTGRDPNDVRPIQARLLALS*48GPGGGRGRGS*58LL
LRRGFS*66DSGGGPPAKQRDLEGAVSRLGGERRTRRES*96RQES*100DPEDDDVKKPALQS*114S*115VVATSKERS*125TERPLFQDQNTDEKETPERPGPIFGLLMGTLQKFKQESTVATERQKRRQEIEQKLE
VQAEEERKQVENERRELFEERRAKQTELRLLEQKVELAQLQEEWNEHNAKIIKYIRTKTK
PHLFYIPGRMCPAPKLIEESQRKTNALFEGRRIEFAEQINKMEARPRRQSMKEKEHQVVV
RNEEQKSEQEEGKVAPRTRVMLRALDDLVARVGTPSPRRGSGEEEEKEIPIVHS*354DAEKEQ
EEEEQKQEMEVKMEEETEVRES*382EKQQDS*388QPEEVMDVLEMVESVKNVIAEQEVMETNQVER
VEPSENEASKELEPEMEFEIEPDKECKSLS*450PGKENAS*457TLEMENEPEEKEEKESEPQPEPM
AQPQAQSLPQPQPQRHRQSQSQPQQYSSPPPLSQPETLPLAVSQPPPQLIQRQGHLPPER
KEFLVESVKLTEVPTEPVLTVHSES*565KYETKTRSRSRGRARNRTSKSRSRSSSSSSSSSSS
TSSSSGSSSSSGSSSSRTSSSSSSTSGSSSRDSSSSTTSSSESRSRSRGRGHNRDRKHRR
SVDRKRRDAS*670GLERSHKSAKGGSSRDAKAVS*691SSGMPRFKPGQL
|
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| Predicted Disorder Regions | 50-55, 75-134, 333-533, 567-699 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | . Residues 635-700 comprise a serine-rich domain. Serines comprise 48 of the 65 residues. The polyserine domain may be highly flexible and may represent a "hot spot" for the phosphorylation of pinin.contains motifs recognized by Ca+2/calmodulin protein kinases (RXXS), c-AMP--dependent kinases (XRRXSX), c-GMP--dependent protein kinase (XSRX), protein kinase C (XRXXSX), and casein kinase 2(XSXXEX).Serine on these sites are highly phosphorylated |
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| Bibliography | Ouyang P, Sugrue SP. Characterization of pinin, a novel protein associated with the desmosome-intermediate filament complex. J Cell Biol. 1996 Nov;135(4):1027-42. doi: 10.1083/jcb.135.4.1027. PMID: 8922384; PMCID: PMC2133386. |
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