Primary Information
BoMiProt ID	Bomi8028
Protein Name	Phytanoyl-CoA dioxygenase domain-containing protein 1
Organism	Bos taurus
Uniprot ID	Q0IIB1
Milk Fraction	Exosomes
Ref Sequence ID	NP_001069711.1
Aminoacid Length	291
Molecular Weight	32539
FASTA Sequence	Download
Gene Name	PHYHD1
Gene ID	540828
Protein Existence Status	Reviewed
Secondary Information
Protein Function	PHYHD1 might play a role in the hydroxylation of fatty acids and interact with some fatty acids or derivatives thereof.
PTMs	Phosphorylation at Thr
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	>sp|Q0IIB1|PHYD1_BOVIN Phytanoyl-CoA dioxygenase domain-containing protein 1 OS=Bos taurus OX=9913 GN=PHYHD1 PE=2 SV=1 MACLSPSQLQKFQEDGFLVLEGFLSADECEAMQRRIDEIVAKMDVPLHCRTEFST*55QEEEQ LRAQGSTDYFLSSGDKIRFFFEKGVFDKQGNFLVPPEKSINKIGHALHALDPIFRCVTHS HKVQALARSLGLQMPVVVQSMYIFKQPHFGGEVAPHQDASFLYTEPLGRVLGLWIALEDA MLENGCLWFIPGSHTGGVSRRMVRTPAGSVPGTSFLGSEPIRDNSLFVPTPVLRGALVLI HGEVVHKSEQNLSDRSRQAYTFHLMEAAGTIWSPDNWLQPTPELPFPPLYT
Predicted Disorder Regions	NA
DisProt Annotation
TM Helix Prediction	No TM helices
Additional Comments	Silencing of PHYHD1 leads to the downregulation of many chorion protein genes, thus directly causing giant eggs.Mutation of PHYHD1 may cause abnormal production and secretion of vitellogenin, resulting in abnormal production and secretion of yolk proteins.
Bibliography	1.Chen A, Liao P, Li Q, Zhao Q, Gao M, Wang P, Liu Z, Meng G, Dong Z, Liu M. phytanoyl-CoA dioxygenase domain-containing protein 1 plays an important role in egg shell formation of silkworm (Bombyx mori). PLoS One. 2021 Dec 30;16(12):e0261918. doi: 10.1371/journal.pone.0261918. PMID: 34968397; PMCID: PMC8717975. 2.Zhang Z, Kochan GT, Ng SS, Kavanagh KL, Oppermann U, Schofield CJ, et al.. Crystal structure of PHYHD1A, a 2OG oxygenase related to phytanoyl-CoA hydroxylase. Biochem Biophys Res Commun. 2011, 408(4): 553–558. doi: 10.1016/j.bbrc.2011.04.059