Search by BoMiProt ID - Bomi7995

Primary Information

BoMiProt ID Bomi7995
Protein Name Phospholipase A2
Organism Bos taurus
Uniprot IDP00593
Milk FractionWhey,MFGM
Ref Sequence ID NP_777071.2
Aminoacid Length 145
Molecular Weight 16002
FASTA Sequence Download
Gene Name PLA2G1B
Gene ID 282457
Protein Existence Status reviewed

Secondary Information

Presence in other biological fluids/tissue/cells Keratinocytes
Protein Function Secretory calcium-dependent phospholipase A2 that primarily targets dietary phospholipids in the intestinal tract. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols.
Biochemical Properties Binds 1 Ca2+ ion per subunit.molecular weight of 13 782 and consists of a single polypeptide chain of 123 amino acids cross-linked by seven disulfide bridges. asparagine at position 6 in the bovine phospholipase A,
Significance in milk Affects inflammatory responses in bovine mammary epithelial cells
PTMs Autocatalytic cleavage, Disulfide bond, Pyrrolidone carboxylic acid, Proteolytic cleavage
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
SCOP Class : All alpha proteins
Fold : Phospholipase A2, PLA2
Superfamily : Phospholipase A2, PLA2
Family : Vertebrate phospholipase A2
Domain Name : 1G4I A:1-123

CATH Matched CATH superfamily
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs Activated by trypsin cleavage in the duodenum. Can also be activated by thrombin or autocatalytically.
Bibliography Fleer EA, Verheij HM, De Haas GH. The primary structure of bovine pancreatic phospholipase A2. Eur J Biochem. 1978 Jan 2;82(1):261-9. doi: 10.1111/j.1432-1033.1978.tb12019.x. PMID: 620674.