Primary Information |
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| BoMiProt ID | Bomi7962 |
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| Protein Name | Phosphatidylinositol-glycan-specific phospholipase D/Glycoprotein phospholipase D/Glycosyl-phosphatidylinositol-specific phospholipase D |
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| Organism | Bos taurus |
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| Uniprot ID | P80109 |
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| Milk Fraction | Whey,MFGM |
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| Ref Sequence ID | NP_777241.1 |
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| Aminoacid Length | 839 |
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| Molecular Weight | 92602 |
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| FASTA Sequence |
Download |
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| Gene Name | GPLD1/PIGPLD |
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| Gene ID | 287025 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane. |
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| Biochemical Properties | C terminal is important for activity.Tyr-811 may play a major role in maintaining the biological activity of GPI-PLD.insulin activates GPLD1 and induces GPI hydrolysis |
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| PTMs | Glycosylated |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|P80109|PHLD_BOVIN Phosphatidylinositol-glycan-specific phospholipase D OS=Bos taurus OX=9913 GN=GPLD1 PE=1 SV=1
MSAFRFWSGLLMLLGFLCPRSSPCGISTHIEIGHRALEFLHLQDGSINYKELLLRHQDAY
QAGSVFPDSFYPSICERGQFHDVSESTHWTPFLN*94ASVHYIRKNYPLPWDEDTEKLVAFLF
GITSHMVADVNWHSLGIEQGFLRTMAAIDFHNSYPEAHPAGDFGGDVLSQFEFKFNYLSR
HWYVPAEDLLGIYRELYGRIVITKKAIVDCSYLQFLEMYAEMLAISKLYPTYSVKSPFLV
EQFQEYFLGGLEDMAFWSTNIYHLTSYMLKN*271GTSNCNLPENPLFITCGGQQN*292NTHGSKVQ
KNGFHKN*307VTAALTKNIGKHIN*321YTKRGVFFSVDSWTMDSLSFMYKSLERSIREMFIGSSQP
LTHVSSPAASYYLSFPYTRLGWAMTSADLNQDGYGDLVVGAPGYSHPGRIHVGRVYLIYG
NDLGLPRIDLDLDKEAHGILEGFQPSGRFGSAVAVLDFNVDGVPDLAVGAPSVGSEKLTY
TGAVYVYFGSKQGQLSSSPN*500VTISCQDTYCNLGWTLLAADVNGDSEPDLVIGSPFAPGGG
KQKGIVAAFYSGSSYSSREKLNVEAANWMVKGEEDFAWLGYSLHGVNVNN*590RTLLLAGSPT
WKDTSSQGHLFRTRDEKQSPGRVYGYFPPICQSWFTISGDKAMGKLGTSLSSGHVMVN*658GT
RTQVLLVGAPTQDVVSKVSFLTMTLHQGGSTRMYELTPDSQPSLLSTFSGNRRFSRFGGV
LHLSDLDNDGLDEIIVAAPLRITDATAGLMGEEDGRVYVFNGKQITVGDVTGKCKSWVTP
CPEEKAQYVLISPEAGSRFGSSVITVRSKEKNQVIIAAGRSSLGARLSGVLHIYRLGQD
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | no TM helices |
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| Significance of PTMs | glycosylation is important for interaction with other factors. |
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| Bibliography | Stadelmann B, Bütikofer P, König A, Brodbeck U. The C-terminus of glycosylphosphatidylinositol-specific phospholipase D is essential for biological activity. Biochim Biophys Acta. 1997 Feb 4;1355(2):107-13. doi: 10.1016/s0167-4889(96)00119-x. PMID: 9042330. |
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