Primary Information |
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| BoMiProt ID | Bomi7945 |
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| Protein Name | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma/Phosphatidylinositol 5-phosphate 4-kinase type II gamma/PI(5)P 4-kinase type II gamma/PIP4KII-gamma |
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| Organism | Bos taurus |
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| Uniprot ID | Q0P5F7 |
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| Milk Fraction | whey |
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| Ref Sequence ID | NP_001069664.1 |
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| Aminoacid Length | 421 |
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| Molecular Weight | 47142 |
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| FASTA Sequence |
Download |
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| Gene Name | PIP4K2C/PIP5K2C |
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| Gene ID | 540005 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Protein Function | It behaves as phosphatidylinositol 5-phosphate 4-kinase but shows significantly lower enzymatic activity. It may be a GTP sensor as it has higher GTP-dependent kinase activity than ATP-dependent kinase activity. |
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| Biochemical Properties | Interacts with PIP5K1A; the interaction inhibits PIP5K1A kinase activity |
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| PTMs | Acetylation and Phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q0P5F7|PI42C_BOVIN Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma OS=Bos taurus OX=9913 GN=PIP4K2C PE=2 SV=1
MASSSVPPTAVPAATAAPGAGFGFAS*26KTKKKHFVQQKVKVFRAADPLVGVFLWGVAHSIN
ELSQVPPPVMLLPDDFKASSKIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFGIDDQ
DYLVSLTRSPPTESEGSDGRFLISYDRTLVIKEVSSEDIADMHSNLSNYHQYIVKCHGNT
LLPQFLGMYRVSVDSEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTL
KDMDFLNKNQKVYIGEEEKKVFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEDG
PVREEESEGDGDCGLTGPPAPVGSYGTSPEGIGGYIHSHRPLGPGEFES*349FIDVYAIRSAE
GAPQKEVYFMGLIDILTQYDAKKKAAHAAKTVKHGAGAEISTVHPEQYAKRFLDFITNIF
A
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| Predicted Disorder Regions | 1-38, 129-137, 294-337, 389-394 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | phosphorylation is induced by EGF |
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| Bibliography | Lima, K., Coelho-Silva, J. L., Kinker, G. S., Pereira-Martins, D. A., Traina, F., Fernandes, P., Markus, R. P., Lucena-Araujo, A. R., & Machado-Neto, J. A. (2019). PIP4K2A and PIP4K2C transcript levels are associated with cytogenetic risk and survival outcomes in acute myeloid leukemia. Cancer genetics, 233-234, 56–66. https://doi.org/10.1016/j.cancergen.2019.04.002 |
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