Primary Information |
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| BoMiProt ID | Bomi7919 |
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| Protein Name | PHD finger protein 20-like protein 1 |
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| Organism | Bos taurus |
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| Uniprot ID | A2VE56 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001075901.1 |
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| Aminoacid Length | 316 |
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| Molecular Weight | 36160 |
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| FASTA Sequence |
Download |
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| Gene Name | PHF20L1 |
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| Gene ID | 511990 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | histone methylation reader protein,regulation of transcription by RNA pol II.act on both methylated Lys-42 and Lys-117 to prevent SOX2 proteolysis. |
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| Biochemical Properties | recognizes histone H3K4me2 via its PHD finger, and the H3K4me2-binding function of the PHD finger is essential for PHF20-dependent histone acetylation.Also contain WD40 repeats, CW domains, PWWP domains, and the royal superfamily, including proteins with chromodomains, TUDOR domains, and malignant brain tumor (MBT) repeats.TUDOR domain–containing proteins (TDRDs) have the potential to recognize histone methylation. |
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| PTMs | Isopeptide bond, Ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | 1-11, 134-148, 154-171, 178-316 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | loss of either LSD1 or PHF20L1 destabilizes SOX2 protein and impairs the self-renewal and pluripotency of mouse ES cells |
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| Bibliography | 1.Hou Y, Liu W, Yi X, Yang Y, Su D, Huang W, Yu H, Teng X, Yang Y, Feng W, Zhang T, Gao J, Zhang K, Qiu R, Wang Y. PHF20L1 as a H3K27me2 reader coordinates with transcriptional repressors to promote breast tumorigenesis. Sci Adv. 2020 Apr 15;6(16):eaaz0356. doi: 10.1126/sciadv.aaz0356. PMID: 32494608; PMCID: PMC7159910. 2.Zhang C, Leng F, Saxena L, Hoang N, Yu J, Alejo S, Lee L, Qi D, Lu F, Sun H, Zhang H. Proteolysis of methylated SOX2 protein is regulated by L3MBTL3 and CRL4DCAF5 ubiquitin ligase. J Biol Chem. 2019 Jan 11;294(2):476-489. doi: 10.1074/jbc.RA118.005336. Epub 2018 Nov 15. PMID: 30442713; PMCID: PMC6333883. |
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