Primary Information |
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| BoMiProt ID | Bomi7910 |
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| Protein Name | PH and SEC7 domain-containing protein 1/Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6/Exchange factor for ARF6/Exchange factor for ARF6 A/Pleckstrin homology and SEC7 domain-containing protein 1 |
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| Organism | Bos taurus |
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| Uniprot ID | F1MUS9 |
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| Milk Fraction | whey |
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| Ref Sequence ID | NP_001178404.1 |
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| Aminoacid Length | 1026 |
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| Molecular Weight | 109765 |
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| FASTA Sequence |
Download |
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| Gene Name | PSD |
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| Gene ID | 523124 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Protein Function | It is a guanine nucleotide exchange factor for ARF6. Involved in cytoskeletal remodeling.Also regulates the membrane trafficking of small G proteins.PSD can regulate Rac1 which plays a pivotal role in inducing apoptosis in response to stimuli such as UV light, tumor necrosis factor-α and Fas. |
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| Biochemical Properties | The 5′-end of the PSD gene contains five CpG islands, suggesting that its expression may be controlled by epigenetic modification. |
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| PTMs | Phsophorylation via CaMKII pathway |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|F1MUS9|PSD1_BOVIN PH and SEC7 domain-containing protein 1 OS=Bos taurus OX=9913 GN=PSD PE=2 SV=1
MAQGAMRFCSEGDCAISPPRCPRRWLPEGPVPQSPPASMYGSTGSLLRRVAGPGPRSREL
GRVTAPCTPLRGPPSPRIAPSPWAPSSPTGQPPPGARSSVVIFRFVEKASVRPLNGLPAP
GGLSRS*126WDLGGVSPPRPTPALGPGSHQKLRLEASTS*156DPLPAGGGSARPGTQGLLQGPPTQ
PQVGADGLYSSLPNGLGGPSEHLATLFRGPADTGLLNQGDIWSSPREVSSHAQRIARAKW
EFFYGSLDPPSSGAKPPEQAPPSPPGVGSGQGSGVAVGRAAKYSETDLDTVPLRCYRETD
IDEVLTEREEADSAIESQPSSEGLPGTARPPAPRPGPCLGPHPSLGSGNEDEDEAGGEED
VDDEVFEASEGARPGTRMPHSGPLKSPLPFLPGTSPSADGPDSFSCVFEAILESHRAKGT
SYTSLASLEALASPGPTQSPFFTFELPPQPPAPRPDPPAPAPLAPLEPDSGTSSAADGPW
TQRGEEEEAEAGAKQTPGRDPPSPCHSEDSFGLGAAPLGSEPPLNQLVSDSDSELDSTER
LALGSTDTLSNGQKADLEAAQRLAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFF
VFTGMTLDQALRVFLKELALMGETQERERVLAHFSQRYFQCNPGALSSEDGAHTLTCALM
LLNTDLHGHNIAETHDLRRLHRYLEGLNEGGDFPRELLKALYSSIKNEKLQWAIDEEELR
RS*722LSELADPNPKVIKRVSGGSGSGSSPFLDLTPEPGAAVYKHGALVRKVHADPDCRKTPR
GKRGWKNFHGILKGMILYLQKEEYQPGKALSEAELKNAISIHHALATRASDYSKRPHVFY
LRTADWRVFLFQAPSLEQMQSWITRINVVAAMFSAPPFPAAVSSQKKFSRPLLPSAATRL
SQEEQVRTHEAKLKAMASELREHRATQLTKKARGKEAEEQRQKEAYLEFEKSRYGTYAAL
LRVKLKAGSEELDAVEAAVAQAGGTEDGLPPPHSSPSLPANTSSQPRAQCSDSEARAGAG
SGRWKP
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| Predicted Disorder Regions | 283-407, 441-532, 996-1024 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | PSD gene may function as a tumor suppressor in gastric cancer suggesting a vital role for DNA methylation and histone modification in PSD silencing. |
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| Bibliography | 1.Zhu X, Liu J, Xu X, Zhang C, Dai D. The Pleckstrin and Sec7 domain-containing gene as a novel epigenetic modification marker in human gastric cancer and its clinical significance. Int J Oncol. 2015 Jan;46(1):195-204. doi: 10.3892/ijo.2014.2736. Epub 2014 Oct 30. Erratum in: Int J Oncol. 2022 Mar;60(3): PMID: 25355626. 2.Murphy, J. A., Jensen, O. N., & Walikonis, R. S. (2006). BRAG1, a Sec7 domain-containing protein, is a component of the postsynaptic density of excitatory synapses. Brain research, 1120(1), 35–45. https://doi.org/10.1016/j.brainres.2006.08.096 |
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