Primary Information |
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| BoMiProt ID | Bomi7908 |
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| Protein Name | PGC-1 and ERR-induced regulator in muscle protein 1/PPARGC1 and ESRR-induced regulator in muscle 1/Peroxisome proliferator-activated receptor gamma coactivator 1 and estrogen-related receptor-induced regulator in muscle 1 |
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| Organism | Bos taurus |
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| Uniprot ID | A5D7L8 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001091517.1 |
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| Aminoacid Length | 901 |
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| Molecular Weight | 94210 |
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| FASTA Sequence |
Download |
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| Gene Name | PERM1 |
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| Gene ID | 520080 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Perm1 interacts with CaMKII and activates the CaMKII-MEF2 pathway.In endurance training, Perm1 impacts muscle oxidative metabolism pathway responses. |
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| Significance in milk | skeletal muscle development |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | (1-28), (47-67), (186-196), (252-274), (291-294), (319-485), (576-582), (684-688), (709-729), (798-806), (894-901) |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | Perm1 is important for skeletal muscle adaptation to endurance training |
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| Bibliography | Cho Y, Tachibana S, Hazen BC, Moresco JJ, Yates JR 3rd, Kok B, Saez E, Ross RS, Russell AP, Kralli A. Perm1 regulates CaMKII activation and shapes skeletal muscle responses to endurance exercise training. Mol Metab. 2019 May;23:88-97. doi: 10.1016/j.molmet.2019.02.009. Epub 2019 Feb 27. PMID: 30862473; PMCID: PMC6480336. |
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