Primary Information |
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| BoMiProt ID | Bomi7907 |
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| Protein Name | Peroxisomal N(1)-acetyl-spermine/spermidine oxidase/Polyamine oxidase |
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| Organism | Bos taurus |
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| Uniprot ID | Q865R1 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001013620.2 |
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| Aminoacid Length | 512 |
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| Molecular Weight | 56325 |
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| FASTA Sequence |
Download |
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| Gene Name | PAOX/PAO |
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| Gene ID | 282639 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Involved in Spermidine Reduction of Transglutaminase Type 2-Catalyzed β H-Crystallins Polymerization in Calcium-Induced Experimental Cataract |
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| Biochemical Properties | The catabolism of spermine to spermidine utilizes either the one-step enzymatic reaction of spermine oxidase (SMO) or the two-step process of spermidine/spermine N (1)-acetyltransferase (SSAT) coupled with the peroxisomal enzyme N (1)-acetylpolyamine oxidase. |
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| PTMs | Acetylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | The acetylated polyamines have two potential fates. First, acetylated polyamines can be exported from the cell. Second, acetylated spermidine and spermine are substrates for the FADdependent, peroxisomal APAO ( |
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| Additional Comments | The increase of endogenous SPD in the cultured rabbit lens showed the activation of a flavin adenine dinucleotide (FAD)-dependent polyamine oxidases |
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| Bibliography | 1.Battaglia V, DeStefano Shields C, Murray-Stewart T, Casero RA Jr. Polyamine catabolism in carcinogenesis: potential targets for chemotherapy and chemoprevention. Amino Acids. 2014 Mar;46(3):511-9. doi: 10.1007/s00726-013-1529-6. Epub 2013 Jun 15. PMID: 23771789; PMCID: PMC3795954. 2.Mischiati C, Feriotto G, Tabolacci C, Domenici F, Melino S, Borromeo I, Forni C, De Martino A, Beninati S. Polyamine Oxidase Is Involved in Spermidine Reduction of Transglutaminase Type 2-Catalyzed βH-Crystallins Polymerization in Calcium-Induced Experimental Cataract. Int J Mol Sci. 2020 Jul 30;21(15):5427. doi: 10.3390/ijms21155427. PMID: 32751462; PMCID: PMC7432200. |
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