Primary Information |
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| BoMiProt ID | Bomi7879 |
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| Protein Name | Peptidyl-prolyl cis-trans isomerase F, mitochondrial(PPIase F)/Cyclophilin D/Cyclophilin F/Rotamase F |
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| Organism | Bos taurus |
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| Uniprot ID | P30404 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001001597.1 |
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| Aminoacid Length | 208 |
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| Molecular Weight | 22019 |
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| FASTA Sequence |
Download |
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| Gene Name | PPIF/CYP3 |
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| Gene ID | 414346 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Cyclophilin D regulates necrosis, but not apoptosis, of murine eosinophils |
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| Biochemical Properties | Cyclophilin D belongs to the cyclophilin family, has peptidyl-prolyl cis-trans isomerase activity, and is uniquely located in the mitochondrial matrix. |
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| PTMs | Acetylation at Lys |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | 25-45, 114-120 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | The genetic ablation of cyclophilin D or its inhibition by cyclosporin A results in accelerated proton pumping by ATP hydrolysis, opposing a further decrease in membrane potential and promoting high matrix phosphate levels. |
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| Bibliography | 1.Chinopoulos C, Adam-Vizi V. Modulation of the mitochondrial permeability transition by cyclophilin D: moving closer to F(0)-F(1) ATP synthase? Mitochondrion. 2012 Jan;12(1):41-5. doi: 10.1016/j.mito.2011.04.007. Epub 2011 May 8. PMID: 21586346. 2.Zhu X, Hogan SP, Molkentin JD, Zimmermann N. Cyclophilin D regulates necrosis, but not apoptosis, of murine eosinophils. Am J Physiol Gastrointest Liver Physiol. 2016 Apr 15;310(8):G609-17. doi: 10.1152/ajpgi.00389.2015. Epub 2016 Feb 18. PMID: 26893161; PMCID: PMC4836130. |
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