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Primary Information | |
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| BoMiProt ID | Bomi7878 |
| Protein Name | Peptidyl-prolyl cis-trans isomerase D/40 kDa peptidyl-prolyl cis-trans isomerase/Cyclophilin-40/Estrogen receptor-binding cyclophilin |
| Organism | Bos taurus |
| Uniprot ID | P26882 |
| Milk Fraction | Exosomes |
| Ref Sequence ID | NP_776578.1 |
| Aminoacid Length | 370 |
| Molecular Weight | 40620 |
| FASTA Sequence | Download |
| Gene Name | PPID |
| Gene ID | 281420 |
| Protein Existence Status | Reviewed |
Secondary Information | |
| Presence in other biological fluids/tissue/cells | heart, thymus and brain. |
| Protein Function | Cyclophilin 40 regulates Hsp90 ATPase activity during receptor-Hsp90 assembly. |
| Biochemical Properties | Cyclophilin 40, a divergent loop cyclophilin,contains a C-terminal tetratricopeptide repeat domain through which it shares structural identity with FK506-binding protein 52 (FKBP52) and other partner cochaperones in steroid receptor-heat shock protein 90 (Hsp90) complexes. |
| PTMs | N6-acetylation at Lysine,Phosphorylation at Serine |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | >sp|P26882|PPID_BOVIN Peptidyl-prolyl cis-trans isomerase D OS=Bos taurus OX=9913 GN=PPID PE=1 SV=6 MSHPS*5PQAKPSNPSNPRVFFDVDIGGERVGRIVLELFADIVPKTAENFRALCTGEKGIGP TTGKPLHFKGCPFHRIIKKFMIQGGDFSNQNGTGGESIYGEKFEDENFHYKHDKEGLLSM ANAGSNTNGSQFFITTVPTPHLDGKHVVFGQVIKGMGVAKILENVEVKGEKPAKLCVIAE CGELKEGDDWGIFPKDGS*198GDSHPDFPEDADVDLKDVDKILLISEDLKNIGNTFFKSQNWE MAIKKYTKVLRYVEGSRAAAEDADGAKLQPVALSCVLNIGACKLKMSDWQGAVDSCLEAL EIDPSNTKALYRRAQGWQGLKEYDQALADLKKAQEIAPEDKAIQAELLKVKQKIKAQKDK EKAAYAKMFA |
| SCOP | Class : All alpha proteins Fold : alpha-alpha superhelix Superfamily : TPR-like Family : Tetratricopeptide repeat (TPR) Domain Name : 1IHG A:197-365 Class : All beta proteins Fold : Canonical cyclophilin-type beta(8)-barrel Superfamily : Cyclophilin-like Family : Cyclophilin peptidylprolyl isomerase-like Domain Name : 1IHG A:2-196 |
| CATH | Matched CATH superfamily 1.10.150.160 |
| Predicted Disorder Regions | 1-17, 90-97, 191-209, 351-365 |
| DisProt Annotation | |
| TM Helix Prediction | No TM helices |
| PDB ID | 1IHG, 1IIP, |
| Bibliography | 1.Ratajczak T, Ward BK, Cluning C, Allan RK. Cyclophilin 40: an Hsp90-cochaperone associated with apo-steroid receptors. Int J Biochem Cell Biol. 2009 Aug-Sep;41(8-9):1652-5. doi: 10.1016/j.biocel.2009.03.006. Epub 2009 Mar 24. PMID: 19433306. |