Primary Information
BoMiProt ID	Bomi7873
Protein Name	Peptidase inhibitor 16(PI-16)/CD_antigen: CD364
Organism	Bos taurus
Uniprot ID	Q58D34
Milk Fraction	Whey
Ref Sequence ID	NP_001019658.1
Aminoacid Length	464
Molecular Weight	49327
FASTA Sequence	Download
Gene Name	PI16
Gene ID	507058
Protein Existence Status	reviewed
Secondary Information
Protein Function	is a membrane-tethered regulator of chemerin processing in the myocardium.A member of the CAP family of proteins which we found to be highly upregulated in cardiac disease.
PTMs	glycosylation
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	>sp|Q58D34|PI16_BOVIN Peptidase inhibitor 16 OS=Bos taurus OX=9913 GN=PI16 PE=2 SV=1 MHGSGSLLACLLPPLLLLGAAPGPAGALSEEEKHVMVELHNLYRTQVSPPATNMLQMRWD EELAAFAKAYAQQCVWGHNKERGRRGENLFAITGEGLDVPLAMEEWHHERLEHYN*114SAISC AAGQMCGHYTQVVWAKTERIGCGSHFCEKLQGVEETNIHLLVCNYEPPGNVKGQRPYQEG TPCSQCPLGYHCKNSLCEPIRGPEEAQDLSSLVPEAPSSLATEASSSRREGIDSSLATEP PPFLVTEVSGSLATKVLSSVETKAPSSLVTEDSPSMATKTPLSLATKVPSVLATHSLLSL DKRPATLLPKSTHDPIPKSADKEASSTRMPSRIPESSLHPKISLMGTREPLPLSQEEGEA EAELAHCSEILASVFPAQEKPGELQTTLKHKGHSSSKSLSNSPSASATANAVGGRTLALQ SSLPDAEGPGKHGFRSGSNASPGHVGGLLLGLLLLLPLVLAGIF
Predicted Disorder Regions	2 disordered segments; (214-412), (421-441)
DisProt Annotation
TM Helix Prediction	1TMH; (445-463)
Significance of PTMs	N glycosylated
Bibliography	Regn M, Laggerbauer B, Jentzsch C, Ramanujam D, Ahles A, Sichler S, Calzada-Wack J, Koenen RR, Braun A, Nieswandt B, Engelhardt S. Peptidase inhibitor 16 is a membrane-tethered regulator of chemerin processing in the myocardium. J Mol Cell Cardiol. 2016 Oct;99:57-64. doi: 10.1016/j.yjmcc.2016.08.010. Epub 2016 Aug 15. PMID: 27539859.