Primary Information |
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| BoMiProt ID | Bomi7840 |
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| Protein Name | Paternally-expressed gene 3 protein |
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| Organism | Bos taurus |
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| Uniprot ID | Q6H236 |
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| Milk Fraction | Whey |
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| Aminoacid Length | 2387 |
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| Molecular Weight | 264828 |
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| FASTA Sequence |
Download |
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| Gene Name | PEG3 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | The structure of SCAN domain from PEG3, a predicted transcription factor,serves
to identify key residues important to the creation of the PEG3-
SCAN dimer interface. |
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| Biochemical Properties | The protein carries twelve zinc finger DNAbinding motifs, which are an important component of transcription. These zinc fingers are classed as Cys2-His2 Kru¨ppel-type motifs where metal ion coordination helps to stabilize a simple bba fold |
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| PTMs | Omega-N-methylation at rginine,Phosphorylation at Ser/Thr |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | Phosphorylation by casein kinase II upon estrogen stimulation, induces the release by KANK2 of NCOA1 and its translocation to the nucleus where NCOA1 can activate gene transcription |
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| Bibliography | 1.Rimsa V, Eadsforth TC, Hunter WN. Structure of the SCAN domain of human paternally expressed gene 3 protein. PLoS One. 2013 Jul 23;8(7):e69538. doi: 10.1371/journal.pone.0069538. PMID: 23936039; PMCID: PMC3720700. 2.Relaix F, Weng X, Marazzi G, Yang E, Copeland N, et al. (1996) Pw1, a novel
zinc finger gene implicated in the myogenic and neuronal lineages. Dev Biol
177: 383–396. 3.. Miller J, McLachlan AD, Klug A (1985) Repetitive zinc-binding domains in the
protein transcription factor III A from Xenopus oocytes. EMBO J 4: 1609–1614.
4. Berg JM (1988) Proposed structure for the zinc-binding domains from transcription factor IIIA and related proteins. Proc Natl Acad Sci U S A 85: 99–102.
5. Lee MS, Gippert GP, Soman KV, Case DA, Wright PE (1989) Threedimensional solution structure of a single zinc finger DNA-binding domain.
Science 245: 635–637. |
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