Primary Information
BoMiProt ID	Bomi7807
Protein Name	Pantothenate kinase 3/Pantothenic acid kinase 3
Organism	Bos taurus
Uniprot ID	Q08DA5
Milk Fraction	Exosomes,MFGM
Ref Sequence ID	NP_001068931.1
Aminoacid Length	370
Molecular Weight	41117
FASTA Sequence	Download
Gene Name	PANK3
Gene ID	510749
Protein Existence Status	Reviewed
Secondary Information
Presence in other biological fluids/tissue/cells	mammary gland
Protein Function	Pantothenate kinases (PanK) are the regulatory enzymes that control the rate of CoA biosynthesis and the concentration of intracellular CoA.
Biochemical Properties	There are four characterized isoforms of PanK, PanK1α, PanK1β, PanK2 and PanK3.All four proteins share homologous catalytic core domains of approximately 350 amino acids. The enzymes function as homodimers with two equivalent active sites formed by a head-to-tail juxtaposition of the monomers. PanK3 and PanK1β contain only the catalytic core domain
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	NA
Predicted Disorder Regions	NA
DisProt Annotation
TM Helix Prediction	No TM helices
Bibliography	1.Leonardi R, Zhang YM, Yun MK, Zhou R, Zeng FY, Lin W, Cui J, Chen T, Rock CO, White SW, Jackowski S. Modulation of pantothenate kinase 3 activity by small molecules that interact with the substrate/allosteric regulatory domain. Chem Biol. 2010 Aug 27;17(8):892-902. doi: 10.1016/j.chembiol.2010.06.006. PMID: 20797618; PMCID: PMC2929395. 2.The murine pantothenate kinase (Pank1) gene encodes two differentially regulated pantothenate kinase isozymes.Rock CO, Karim MA, Zhang YM, Jackowski S.Gene. 2002 May 29; 291(1-2):35-43. 3.Feedback regulation of murine pantothenate kinase 3 by coenzyme A and coenzyme A thioesters.Zhang YM, Rock CO, Jackowski S.J Biol Chem. 2005 Sep 23; 280(38):32594-601. 4.Coenzyme A: back in action.Leonardi R, Zhang YM, Rock CO, Jackowski S.Prog Lipid Res. 2005 Mar-May; 44(2-3):125-53.