Primary Information |
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BoMiProt ID | Bomi7793 |
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Protein Name | p21-activated protein kinase-interacting protein 1/PAK1-interacting protein 1 |
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Organism | Bos taurus |
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Uniprot ID | Q5EA99 |
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Milk Fraction | Whey |
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Ref Sequence ID | NP_001014852.1 |
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Aminoacid Length | 392 |
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Molecular Weight | 44049 |
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FASTA Sequence |
Download |
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Gene Name | PAK1IP1 |
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Gene ID | 505125 |
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Protein Existence Status | reviewed |
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Secondary Information |
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Protein Function | p21-activated kinase 1 (PAK1) is a serine/threonine kinase that direct cell motility, cytoskeletal remodelling, and has been shown to function as a downstream regulator for various cancer signalling cascades that promote cell proliferation, apoptosis deregulation and hasten mitotic abnormalities, resulting in tumor formation and progression. |
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Biochemical Properties | p21-activated kinase 1 signalling is crucial for activation of the Ras/RAF/MEK/ERK, PI3K/Akt/mTOR and Wnt signalling cascades which regulate cell survival, cell cycle progression, differentiation, and proliferation. |
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PTMs | Phosphorylation at Serine |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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Predicted Disorder Regions | 307-392 |
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DisProt Annotation | |
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TM Helix Prediction | No TM helices |
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Additional Comments | GIT1/βPIX signaling proteins with PAK1 kinase represent a novel regulatory mechanism of microtubule nucleation in interphase cells. |
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Bibliography | 1.Kanumuri R, Saravanan R, Pavithra V, Sundaram S, Rayala SK, Venkatraman G. Current trends and opportunities in targeting p21 activated kinase-1(PAK1) for therapeutic management of breast cancers. Gene. 2020 Nov 15;760:144991. doi: 10.1016/j.gene.2020.144991. Epub 2020 Jul 25. PMID: 32717309. 2.Černohorská M, Sulimenko V, Hájková Z, Sulimenko T, Sládková V, Vinopal S, Dráberová E, Dráber P. GIT1/βPIX signaling proteins and PAK1 kinase regulate microtubule nucleation. Biochim Biophys Acta. 2016 Jun;1863(6 Pt A):1282-97. doi: 10.1016/j.bbamcr.2016.03.016. Epub 2016 Mar 22. Erratum in: Biochim Biophys Acta. 2017 Apr;1864(4):747. PMID: 27012601. |