Primary Information |
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| BoMiProt ID | Bomi7751 |
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| Protein Name | Origin recognition complex subunit 3 |
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| Organism | Bos taurus |
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| Uniprot ID | Q32PJ3 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001033228.1 |
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| Aminoacid Length | 712 |
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| Molecular Weight | 82231 |
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| FASTA Sequence |
Download |
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| Gene Name | ORC3/ORC3L |
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| Gene ID | 523714 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | A component of rigin recognition complex (ORC) that binds origins of replication during initiation of replication. |
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| Biochemical Properties | contains a putative nuclear localization signal and a non-basic helix-loop-helix motif.Near the carboxyl termini of these proteins a winged-helix domain is present that mediates DNA binding. |
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| PTMs | Phosphorylation, Ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q32PJ3|ORC3_BOVIN Origin recognition complex subunit 3 OS=Bos taurus OX=9913 GN=ORC3 PE=2 SV=1
MATSSVSKGCFVFKPNFKKRKIS*23VPIEDYFNKGKNASEDSKLRFETYQLIWQQMKSETER
LQEELNKNLFDSLVEFLQTSHSGLWKNSKDWSCEIKLREIPTAALVLGVNVTDHDLTLRS
LTEVLQNNVTPYVVSLQAKDCPDMKHFLQKLVSQLMDCKVDVQSKEKESVQVIQKNVHYS
MDSLSAWYMSVTQKTDPKMPRKKRTSSSQWQSPPVVLILKDMESFTTKVLQDFIIISSQH
LHEFPLILIFGIATSPVVIHRLLPHAVSSLLCIELFQSLSCKEHLTTVLDKLLLTTQFPF
KLSEKVLQILTNIFLYHDFSIQNFIKGLQLSLLEHFYSQPLSVLCCNLPEAKRRIRFLSA
NQCENIRRLPSFRRYVEKQSSEKQVALLTSDKFLKEETQSLLENLHVYHKNYFLVLRCLH
QFTSSLPKYPLGRQIRELYCMCLEKSIWDSEEYASVLQLLRLLAKDELMAMLQNCFKLFQ
SSSGKELGNTAKRIEEFLAQFQSLDETKEEEDTSQS*516QSKGLQKTDLYHLQKSLLEMKELR
STSKRQTKFEVLREQVVSFVDSLVREYLLPPDTQPLHETLYFSSAHTLRQHLNAAPRIAL
HTALNNPYYYLKNEALRSEEGCIPNVAPDICIAYKLHLECSRLINLVDWSEAFATVVTAA
EKMDANSVTSGERNEIIHARFIRAVSELELLGFIKPTKQKTDHVARLTWGGC
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | ubiquitination is important for efficient DNA replication origin site activation. |
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| Bibliography | 1.Duncker BP, Chesnokov IN, McConkey BJ. The origin recognition complex protein family. Genome Biol. 2009;10(3):214. doi: 10.1186/gb-2009-10-3-214. Epub 2009 Mar 17. PMID: 19344485; PMCID: PMC2690993. |
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