Search by BoMiProt ID - Bomi7751


Primary Information

BoMiProt ID Bomi7751
Protein Name Origin recognition complex subunit 3
Organism Bos taurus
Uniprot IDQ32PJ3
Milk FractionWhey
Ref Sequence ID NP_001033228.1
Aminoacid Length 712
Molecular Weight 82231
FASTA Sequence Download
Gene Name ORC3/ORC3L
Gene ID 523714
Protein Existence Status reviewed

Secondary Information

Protein Function A component of rigin recognition complex (ORC) that binds origins of replication during initiation of replication.
Biochemical Properties contains a putative nuclear localization signal and a non-basic helix-loop-helix motif.Near the carboxyl termini of these proteins a winged-helix domain is present that mediates DNA binding.
PTMs Phosphorylation, Ubl conjugation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|Q32PJ3|ORC3_BOVIN Origin recognition complex subunit 3 OS=Bos taurus OX=9913 GN=ORC3 PE=2 SV=1 MATSSVSKGCFVFKPNFKKRKIS*23VPIEDYFNKGKNASEDSKLRFETYQLIWQQMKSETER LQEELNKNLFDSLVEFLQTSHSGLWKNSKDWSCEIKLREIPTAALVLGVNVTDHDLTLRS LTEVLQNNVTPYVVSLQAKDCPDMKHFLQKLVSQLMDCKVDVQSKEKESVQVIQKNVHYS MDSLSAWYMSVTQKTDPKMPRKKRTSSSQWQSPPVVLILKDMESFTTKVLQDFIIISSQH LHEFPLILIFGIATSPVVIHRLLPHAVSSLLCIELFQSLSCKEHLTTVLDKLLLTTQFPF KLSEKVLQILTNIFLYHDFSIQNFIKGLQLSLLEHFYSQPLSVLCCNLPEAKRRIRFLSA NQCENIRRLPSFRRYVEKQSSEKQVALLTSDKFLKEETQSLLENLHVYHKNYFLVLRCLH QFTSSLPKYPLGRQIRELYCMCLEKSIWDSEEYASVLQLLRLLAKDELMAMLQNCFKLFQ SSSGKELGNTAKRIEEFLAQFQSLDETKEEEDTSQS*516QSKGLQKTDLYHLQKSLLEMKELR STSKRQTKFEVLREQVVSFVDSLVREYLLPPDTQPLHETLYFSSAHTLRQHLNAAPRIAL HTALNNPYYYLKNEALRSEEGCIPNVAPDICIAYKLHLECSRLINLVDWSEAFATVVTAA EKMDANSVTSGERNEIIHARFIRAVSELELLGFIKPTKQKTDHVARLTWGGC
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs ubiquitination is important for efficient DNA replication origin site activation.
Bibliography 1.Duncker BP, Chesnokov IN, McConkey BJ. The origin recognition complex protein family. Genome Biol. 2009;10(3):214. doi: 10.1186/gb-2009-10-3-214. Epub 2009 Mar 17. PMID: 19344485; PMCID: PMC2690993.