Primary Information |
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| BoMiProt ID | Bomi7750 |
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| Protein Name | Origin recognition complex subunit 1 |
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| Organism | Bos taurus |
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| Uniprot ID | Q58DC8 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001014918.1 |
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| Aminoacid Length | 863 |
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| Molecular Weight | 97902 |
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| FASTA Sequence |
Download |
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| Gene Name | ORC1/ORC1L |
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| Gene ID | 513523 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | regulates cell growth and metastasis in glioma by altering activation of ERK and JNK signaling pathway |
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| Biochemical Properties | Origin recognition complex (ORC), a heteromeric six-subunit complex, is the central component of the eukaryotic pre-replication complex. ORC1 primarily regulated the cell cycle and affects apoptotic signaling pathways. |
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| PTMs | Phosphorylation at Ser/Thr,Acetylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q58DC8|ORC1_BOVIN Origin recognition complex subunit 1 OS=Bos taurus OX=9913 GN=ORC1 PE=2 SV=2
MAYYSARLRTRQTYSWVGRPLLDQKLHYQTYKEMSMKREDYSTEIHIQVGQFVLIEGDDD
ENPYVAKLVELFEDDSELYSKKRARVQWFIRFCEVPVCKQHLLGRKPGTQEIFWYDNPTC
NSNISVETIIGSVRVVALAPDEVMPIDLKNKKTFFVKLSWNEKKFKPLPPEVFAQLNKLQ
EDNHRYQKPMQAKTKSAES*199PSWT*203TTEHAVKRIESRHSTSKSRHTASHPVTPRARKRLELS
SFPRTPNTRISPAAS*255CAS*258LDSPGRMKRKVAFSEVMS*276PSKRSLPDGFQTSS*290PALKAPEKTGEIQHSCTKDAKKTSPDHGMILRARAPALKITETSEERTLT*340PIGGGRKSSVVPSVILKPEY
IKRREGKEPEVQDEAPSTSRIRRKSSVLTLNRIRQQLRFLGNSKSDENDEEFLPAAEIS*419D
CDSEEEEASTTPLPRRTPNSVSRNLRSSMKSSLQTPSKTPKKTPEPRTPRDATPRIRSRN
LTAQGPTNMLEEARLRLHVAAVPESLPCREQEFQDIYNFVESKLLDQTGGCMYISGVPGT
GKTATVHEVICCLQQAAQANEVPPFQYIEVNGMKLTEPHQVYVQILQKLTGKRATANHAA
ALLAKRFCTQGSSQETTVLLVDELDLLWTQKQDVMYNLFDWPTHKEARLVVLTIANTMDL
PERIMMNRVSSRLGLTRMCFQPYTHSQLRQILLSRLRHVKAFEDDAIQLVARKVAALSGD
ARRCLDICRRATEICEFSCQKPDSPGLVTTAHLLEAIDEMFSSSYITAIKNSSVLEQSFL
RAILAEFRRSGLEEATFQQVYIQHVALCRMEGLPYPTMSETMAVCSRLGACRLLLVEPSR
NDVLRRVRLNVSQDDVLYALKEE
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | Acetylation and Glycosylation U64 |
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| Additional Comments | OCR1 inhibition reduced invasion and migration, promoted cell apoptosis. In addition, OCR1 overexpression promoted cell proliferation and induced G2 phase arrest. Moreover, OCR1 downregulation suppressed activation of the ERK/JNK signaling pathway. |
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| Bibliography | 1.Xiong W, Xie C, Qiu Y, Tu Z, Gong Q. Origin recognition complex subunit 1 regulates cell growth and metastasis in glioma by altering activation of ERK and JNK signaling pathway. Mol Cell Probes. 2020 Feb;49:101496. doi: 10.1016/j.mcp.2019.101496. Epub 2019 Dec 20. PMID: 31866342. 2.Popova VV, Brechalov AV, Georgieva SG, Kopytova DV. Nonreplicative functions of the origin recognition complex. Nucleus. 2018;9(1):460-473. doi: 10.1080/19491034.2018.1516484. PMID: 30196754; PMCID: PMC6244734. |
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