Primary Information |
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| BoMiProt ID | Bomi7742 |
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| Protein Name | Oncoprotein-induced transcript 3 protein |
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| Organism | Bos taurus |
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| Uniprot ID | Q29RU2 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001039529.1 |
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| Aminoacid Length | 547 |
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| Molecular Weight | 60550 |
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| FASTA Sequence |
Download |
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| Gene Name | OIT3 |
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| Gene ID | 510915 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | OIT3 deficiency impairs uric acid reabsorption in renal tubule.it may also act as a potential therapeutic agent in hyperuricemia and renal dysfunction. |
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| Biochemical Properties | The oncoprotein induced transcript 3 (OIT3), also named liver-specific zona pellucida domain-containing protein (LZP), has been shown to be expressed in kidney, and was confirmed to interact with the Tamm-Horsfall glycoprotein (THP). |
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| PTMs | N-linked Glycosylation at Asn |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q29RU2|OIT3_BOVIN Oncoprotein-induced transcript 3 protein OS=Bos taurus OX=9913 GN=OIT3 PE=2 SV=1
MPQLLLLACLLIIVTRVAPRALDPCSAYISLNEPWRNTEHQFDESRGSPLCDNSVDGEWY
RFTGMAGDAMPTFCIPENHCGTHAPVWLN*89GSHPLEGDGIVQRQACASFNGNCCLWN*116TTVE
VKSCPGGYYVYRLTKPSVCFHVYCGHFYDICDDDCHGSCLGTSECTCAPGTVLGPDRQTC
FDENECEQNNGGCSEICVNLKNSYRCECGIGRVLRSDGKTCEDIEGCHNNNGGCSHSCLT
SETGYQCECPRGLVLSEDNHTCQVPVFCKSNTIEVSIPRDLVGGLELFLTNTSCRGVSN*299G
THVNILFSLKTCGTVVDVVNDKIVASNLVTGLPKQTPGSSGDIIIRTSKLLIPVTCEFPR
LYTISEGYVPNLRNTPLEIMSRSHGIFPFTLEIFKDHEFEEPYREALPTLKLRDSLYFGI
EPLVHVNGLESLVESCFATPTSKIDEIMKYYIIQDGCVSDDSVKQYTSRDHLAKHFQVPV
FKFVGKDHKEVFLHCRVLVCGMLDERSRCAQGCHRRVRREASTEGEDASGPRSQMLTGGP
ISIDWED
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| Predicted Disorder Regions | 521-547 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | Hypouricemic and Nephroprotective Effects of Emodinol in Oxonate-Induced Hyperuricemic Mice are Mediated by Organic Ion Transporters and OIT3 |
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| Bibliography | 1.Hui W, Yongliang Y, Yongde C, Guo L, Li L, Zhonglin Y, Hui J, Qinghua H. Hypouricemic and Nephroprotective Effects of Emodinol in Oxonate-Induced Hyperuricemic Mice are Mediated by Organic Ion Transporters and OIT3. Planta Med. 2016 Mar;82(4):289-297. doi: 10.1055/s-0035-1558212. Epub 2015 Nov 19. PMID: 26584455. 2.Hui W, Yongliang Y, Yongde C, Guo L, Li L, Zhonglin Y, Hui J, Qinghua H. Hypouricemic and Nephroprotective Effects of Emodinol in Oxonate-Induced Hyperuricemic Mice are Mediated by Organic Ion Transporters and OIT3. Planta Med. 2016 Mar;82(4):289-297. doi: 10.1055/s-0035-1558212. Epub 2015 Nov 19. PMID: 26584455. |
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