Primary Information |
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| BoMiProt ID | Bomi7739 |
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| Protein Name | Oligoribonuclease, mitochondrial/RNA exonuclease 2 homolog/Small fragment nuclease |
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| Organism | Bos taurus |
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| Uniprot ID | A2VE52 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001075204.1 |
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| Aminoacid Length | 237 |
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| Molecular Weight | 26885 |
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| FASTA Sequence |
Download |
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| Gene Name | REXO2 |
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| Gene ID | 540139 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | oligoribonuclease activity.ability to degrade small single-stranded RNA and DNA fragments. |
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| Biochemical Properties | REXO2 has conserved two AUG translation initiation sites.3' to 5' exonuclease activity specific.Maintaining Mitochondrial Structure.its depletion Severely Affects Mitochondrial Nucleic Acid Content.Cofactor for this enzyme is Mn2+ or Mg2+. |
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| PTMs | Acetylation and phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A2VE52|ORN_BOVIN Oligoribonuclease, mitochondrial OS=Bos taurus OX=9913 GN=REXO2 PE=2 SV=1
MLGGSLGSRLLRGVGGTRGQFRARGVREGGAAMAAGESMAQRMVWVDLEMTGLDIEKDQI
IEMACLITDSDLNILAEGPNLIIKQPDELLDS*92MSDWCKEHHGKSGLTKAVKESTMTLQQA
EY*122EFLSFVRQQTPPGLCPLAGNSVHADKKFLDKYMPQFMKHLHYRIIDVSTVKELCRRWY
PEEYEFAPKKAASHRALDDISESIKELQFYRNNIFKKKTDEKKRKIIENGENEKTVS
|
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| Predicted Disorder Regions | 2 disordered segments; (1-9), (219-237) |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | REXO2 depletion also has a negative effect on both replication and transcription in mitochondria, causing a robust depletion of mtDNA and of mtRNAs |
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| Bibliography | Bruni F, Gramegna P, Oliveira JM, Lightowlers RN, Chrzanowska-Lightowlers ZM. REXO2 is an oligoribonuclease active in human mitochondria. PLoS One. 2013 May 31;8(5):e64670. doi: 10.1371/journal.pone.0064670. PMID: 23741365; PMCID: PMC3669425. |
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