Primary Information |
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| BoMiProt ID | Bomi7729 |
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| Protein Name | Olfactomedin-like protein 3 |
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| Organism | Bos taurus |
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| Uniprot ID | Q0VCP3 |
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| Milk Fraction | Whey,Casein |
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| Ref Sequence ID | NP_001068665.1 |
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| Aminoacid Length | 406 |
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| Molecular Weight | 45886 |
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| FASTA Sequence |
Download |
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| Gene Name | OLFML3 |
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| Gene ID | 505318 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | dorsoventral patterning during early development.Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation. |
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| Biochemical Properties | 406 amino acid residues.It contains a highly conserved OFL domain at the C-terminal, whereas a more variable coiled-coil domain at N-terminal region |
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| PTMs | Disulfide bond, Glycosylation on Asn |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q0VCP3|OLFL3_BOVIN Olfactomedin-like protein 3 OS=Bos taurus OX=9913 GN=OLFML3 PE=2 SV=1
MGPHTQLLILLLLSWLGPLQGQQHHLVEYMERRLAALEERLAQCQDQSSRHAAELRDFKN
KMLPLLEVAEKEREALRTEADTISGRVDRLEREVDYLETQNPALPCVEVDEKVTGGPGTK
GKGRRNEKYDMITDCGYTISQVRSMKILKRFGGPAGLWTKDPLGPAEKIYVLDGTQNDTA
FVFPRLRDFTLAMAARKASRVRVPFPWVGTGQLVYGGFLYYARRPPGGPGGGGELQNTLQ
LIKFHLAN*248RTVVDSSVFPAEGLIPPYGLTADTYIDLAADEEGLWAVYATREDDRHLCLAK
LDPQTLDTEQQWDTPCPRENAEAAFVICGTLYVVYNTRPASRARIQCSFDASGTLTPERA
ALPYFPRRYGAHASLRYNPRERQLYAWDDGYQIVYKLEMRKKEEEV
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| Predicted Disorder Regions | 1 disordered segment; (104-127), 403rd disordered residue |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | abundant expression in placenta and moderate expression in heart and liver, weak in skeletal muscle, small intestine, lung, and kidney, and very weak in colon, spleen, thymus, and brain.no expression has been detected in peripheral blood leukocytes |
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| Bibliography | Jin Y, Li JL. Olfactomedin-like 3: possible functions in embryonic development and tumorigenesis. Chin Med J (Engl). 2019 Jul 20;132(14):1733-1738. doi: 10.1097/CM9.0000000000000309. PMID: 31261202; PMCID: PMC6759097. |
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