Primary Information |
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| BoMiProt ID | Bomi7728 |
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| Protein Name | Olfactomedin-like protein 2B |
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| Organism | Bos taurus |
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| Uniprot ID | A6QLD2 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001093824.1 |
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| Aminoacid Length | 759 |
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| Molecular Weight | 84493 |
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| FASTA Sequence |
Download |
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| Gene Name | OLFML2B |
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| Gene ID | 513053 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | bind chondroitin sulphate-E and heparin selectively to regulate the binding of CS-E to growth factors,take part in ECM organization. |
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| Biochemical Properties | Contain signal sequence at their N-terminal followed by two tandem CXCXCX9C motifs, a putative coiled-coil region, a serine/threonine-rich region, an OLF domain in their C-terminal, and two or three potential N-glycosylation sites. |
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| Significance in milk | Exosomes |
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| PTMs | O and N glycosylated. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A6QLD2|OLM2B_BOVIN Olfactomedin-like protein 2B OS=Bos taurus OX=9913 GN=OLFML2B PE=2 SV=1
MAKSLLLVLCFALVTTLGWGYSAPPTGTTEPPDVQTVAPTEDETLQNEADNQENVLSQLL
GDYDKVKAVSEGSDCQCKCVVRPLGRDACQRVNAGTSRKEDFYTVETITSGPSCKCACVA
PPSALNPCEGDFRLQKLREADSRDLKLSTIIDMLEGAFYGLDLLKLHSVTTKLVGRVDKL
EEEISKN*187LTKENEQIREDVEEIRTEMNKRGKEN*213CSNNILDSIPDIRSALQRDAAAAYTHP
EYEERFLQEETVSQQIKSIKLLQTRPLAPPEVVKPQRPLQRQVHLRGRPASRPTVIRGIT
YYKAKDPEEENDIEEHQDEFFSGEHGMDLLIEDQLLRHNQLLTSATRRPAATGRSAAVTA
DAGTTSAGTPTTALPSARLPASTAAPSTPDPAVSASVEQFSTPLPTTSVSPDPTEEAVPT
PFTQVPATTVAHTATQQPPASAPPSAAPEDAFVEATHTAPVPPPPVRTDSPGKDSTARQG
TVPPGPTLSPEEEDDIRNVIGRCKDTLSTITGPITQNTYGRNEGAWMKDPLAKDERIYVT
NYYYGNTLVEFRNLENFKQGRWSNSYKLPYSWIGTGHVVYNGAFYYNRAFTRNIIKYDLK
QRYVAAWAMLHDVAYEEATPWRWQGHSDVDFAVDENGLWLIYPALDDEGFSQEVIVLSKL
NAVDLSTQKETTWRTGLRRNLYGNCFVICGVLYAVDSHNQRNAN*704ISYAFDTHTNTQIVPR
LLFENEYSYTTQIDYNPKDRLLYAWDNGHQVTYHVIFAY
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| Predicted Disorder Regions | 23-48, 237-246, 263-266, 304-309, 322-484 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | Lin J, Xu X, Li T, Yao J, Yu M, Zhu Y, Sun D. OLFML2B Is a Robust Prognostic Biomarker in Bladder Cancer Through Genome-Wide Screening: A Study Based on Seven Cohorts. Front Oncol. 2021 Nov 15;11:650678. doi: 10.3389/fonc.2021.650678. PMID: 34868901; PMCID: PMC8634430. |
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