Search by BoMiProt ID - Bomi7683

Primary Information

BoMiProt ID Bomi7683
Protein Name Nucleolar protein 12
Organism Bos taurus
Uniprot IDQ2KIV0
Milk FractionWhey
Aminoacid Length 213
Molecular Weight 24707
FASTA Sequence Download
Gene Name NOL12
Gene ID 615252
Protein Existence Status reviewed

Secondary Information

Protein Function May bind to 28S rRNA.NOL12 repression induces specific changes in nucleolar morphology, with increased nucleolar area but reduced nucleolar number, along with nucleolar accumulation and increased levels of fibrillarin and nucleolin.NOL12 repression leads to stabilization and activation of p53 in an RPL11-dependent manner, which arrests cells at G2 phase and ultimately leads to senescence.The yeast NOL12 homologue Rrp17 was shown to function as a 5′-to-3′ RNA exonuclease for processing of the internal transcribed spacer 1 (ITS1) region of pre-rRNA during ribosome biogenesis.NOL12 regulates nucleolar structure and the protein levels of fibrillarin and nucleolin.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions (1-213)
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography Pinho M, Macedo JC, Logarinho E, Pereira PS. NOL12 Repression Induces Nucleolar Stress-Driven Cellular Senescence and Is Associated with Normative Aging. Mol Cell Biol. 2019 May 28;39(12):e00099-19. doi: 10.1128/MCB.00099-19. PMID: 30988155; PMCID: PMC6549468.