Primary Information
BoMiProt ID	Bomi7683
Protein Name	Nucleolar protein 12
Organism	Bos taurus
Uniprot ID	Q2KIV0
Milk Fraction	Whey
Aminoacid Length	213
Molecular Weight	24707
FASTA Sequence	Download
Gene Name	NOL12
Gene ID	615252
Protein Existence Status	reviewed
Secondary Information
Protein Function	May bind to 28S rRNA.NOL12 repression induces specific changes in nucleolar morphology, with increased nucleolar area but reduced nucleolar number, along with nucleolar accumulation and increased levels of fibrillarin and nucleolin.NOL12 repression leads to stabilization and activation of p53 in an RPL11-dependent manner, which arrests cells at G2 phase and ultimately leads to senescence.The yeast NOL12 homologue Rrp17 was shown to function as a 5′-to-3′ RNA exonuclease for processing of the internal transcribed spacer 1 (ITS1) region of pre-rRNA during ribosome biogenesis.NOL12 regulates nucleolar structure and the protein levels of fibrillarin and nucleolin.
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	NA
Predicted Disorder Regions	(1-213)
DisProt Annotation
TM Helix Prediction	No TM helices
Bibliography	Pinho M, Macedo JC, Logarinho E, Pereira PS. NOL12 Repression Induces Nucleolar Stress-Driven Cellular Senescence and Is Associated with Normative Aging. Mol Cell Biol. 2019 May 28;39(12):e00099-19. doi: 10.1128/MCB.00099-19. PMID: 30988155; PMCID: PMC6549468.