Primary Information |
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| BoMiProt ID | Bomi7527 |
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| Protein Name | NLR family CARD domain-containing protein 4/Ice protease-activating factor |
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| Organism | Bos taurus |
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| Uniprot ID | F1MHT9 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001179252.2 |
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| Aminoacid Length | 1017 |
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| Molecular Weight | 115578 |
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| FASTA Sequence |
Download |
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| Gene Name | NLRC4/IPAF |
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| Gene ID | 512480 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Expression of NLRC4 significantly increased in thyroid tissues from patients with autoimmune thyroiditis (AIT), and enhanced posttranslational maturation of caspase-1, IL-18 and IL-1β was also observed. |
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| Biochemical Properties | Inflammasomes are intracellular multi-protein plats composed of NOD-like receptors (NLRs)/AIM-like receptors, the apoptosis-associated speck-like protein that contains caspase activation recruitment domain (ASC) and the inflammatory effector pro caspase-1.The NLR family, pyrin domain containing 3 (NLRP3),
pyrin domain containing 1 (NLRP1), and caspase activation
recruitment domain containing 4 (NLRC4) are the most studied
intracellular pattern recognition receptors; they are known for
their ability to assemble canonical inflammasomes in response
to specific PAMPs and DAMPs |
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| PTMs | Phosphorylation at Ser |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|F1MHT9|NLRC4_BOVIN NLR family CARD domain-containing protein 4 OS=Bos taurus OX=9913 GN=NLRC4 PE=3 SV=3
MNFIKENSQVLIQRMGMTVIKQILDELFVWNVMNYEEVNVICGEKFEQDAARGVIHMILK
KGSEACNLFLKSLEKWNYPLFQELHGLSLFHQMSEEDLDDLAQELKYFYQSPSFLNFYPL
GEDIDIMFNLKSTFTEPVLWKKDQHHHRLEQLTLSGLLDTLQSPCIIEGESGKGKSTLLQ
RIAMLWASGECQALTKFKLVFFLRLSRAQGGLFETLSDQLLDIPDVISKQTFMARLLKLR
QRVLFLLDGYNEFKAQNCPEIEALIKENHRFKNMVIVTTTTESLRHIRQFGALIAEVGDM
TESSAQALIQEVLRKEFAEDLLLQIQKSRCLRNLMKTPLFVVITCAIQMGKSEFHSHTQT
TLFCTFYDLLINKNRHKRKGLAPSEVTQSLDHCGDLALEGVFSRRFDFEPDDLSNVNEDV
LLTTGLLCKYTAQRFKPKYKFFHQSFQEYTAGRRLSSLLTSGEPAEVTKGNGHLQKMVSI
SDITSKYSNLLLYTCGSSAEATRTVLKHLSSVYQHGSLLGLSVTKRPLWRQES*533MQNMKST
TVQEILKAININSFTECGINLFHESISTSSLSKEFEDFFRGKSLYINSENIPDYLFDFFE
DLPNCASALDFVKLDFYGGAVRDISGNQDQEFSGTYIPSRAVSLFFNWKQEFKTLDVTLR
DFCKLSKKDIKYLEKIFSSATSLRLHIKRCVGMAGSLSSVLSTCKNIHSLIVEASPLTLE
DEQHITSVTNLQTLGVHDLQIQRLPGGLTDNLGNLKNLMKLILDNIQMNEEDALKLAEGL
TNLKKMCLLRLTHLSDIGEGMDYIVKSLSAEPCDLKEIQLVSCCLSGNAVKTLAQNLHNL
ARLSILDLSENHLEKDGKEALQQLIDRLHILEQLTVLMLPWCGDVRVSLARLLEQLERVP
QLVKLGLKNWRLTDAEIRILGVFFEKNPLENFQQLDLAGNCVSSDGWLAFMSGFENLKEL
VFFDFSTKGLLPDASLVRKLSHVLSKLTFLQEVQLVGWQLDDDDVSVLKGAFKLVIA
|
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | Phosphorylation is essential for NLRC4 inflammasome function to promote caspase-1 activation and pyroptosis. |
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| Bibliography | Liu L, Chan C. IPAF inflammasome is involved in interleukin-1β production from astrocytes, induced by palmitate; implications for Alzheimer's Disease. Neurobiol Aging. 2014 Feb;35(2):309-21. doi: 10.1016/j.neurobiolaging.2013.08.016. Epub 2013 Sep 20. Erratum in: Neurobiol Aging. 2014 Jun;35(6):e13. PMID: 24054992; PMCID: PMC3832124. 2.. Schroder K, Tschopp J. The inflammasomes. Cell (2010) 140(6):821–32.
doi:10.1016/j.cell.2010.01.040. 3.Latz E, Xiao TS, Stutz A. Activation and regulation of the inflammasomes. Nat
Rev Immunol (2013) 13(6):397–411. doi:10.1038/nri3452. |
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