Primary Information
BoMiProt ID	Bomi7478
Protein Name	N-fatty-acyl-amino acid synthase/hydrolase PM20D1
Organism	Bos taurus
Uniprot ID	Q2T9M7
Milk Fraction	Whey,MFGM
Ref Sequence ID	NP_001033189.1
Aminoacid Length	503
Molecular Weight	55785
FASTA Sequence	Download
Gene Name	PM20D1
Gene ID	513852
Protein Existence Status	reviewed
Secondary Information
Protein Function	PM20D1 is a secreted enzyme that regulates N-acyl amino acids.Increased PM20D1 or N-acyl amino acid administration augments energy expenditure.
PTMs	Glycosylation
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	>sp|Q2T9M7|P20D1_BOVIN N-fatty-acyl-amino acid synthase/hydrolase PM20D1 OS=Bos taurus OX=9913 GN=PM20D1 PE=2 SV=1 MARPSVCLLASLSALLLGIAAVSRSKGLRGTESQREPRIPSQFSQEQRIAMKEALKGAIQ IPTVSFSPKELN*72TTALAEFGEYIRKVFPTVFHTSFIRHEVVGNYSHLFTIKGSDPSMQPY ILLAHIDVVPAPDKGWDVPPFSGLERDGFIYGRGTLDNKNYLMAILQALELLLIRNYIPR RSFFIALGHDEEISGINGAQKISALLQARGVQLAFVVDEGSFILDGFIPYLKKPFAMVSV SEKGAINLMLQVNTTTGHSSAPPKETSIGILAAAVSRLEQTPMPNMFGSGPLMTAVEQLA NEFPFPTNIVLNNLWLFRPLVSRLMERNYITNSLVRTTTALTMFNAGVKVNVIPPVAEAI INFRLHPAQTVQEVLKLAKDIVADDRIQFHVLDAFDPLPISPSDDQALGYQLLRQTIHSV FPEVNIVAPGTCIGNTDSRHYLNLTTGIYRFNPIYLQPQDFSSIHGINEKISVQAYETQV KFVFEFIQNGDTDEETVPHLHEL
Predicted Disorder Regions	NA
DisProt Annotation
TM Helix Prediction	No TM helices
Bibliography	Long JZ, Svensson KJ, Bateman LA, Lin H, Kamenecka T, Lokurkar IA, Lou J, Rao RR, Chang MR, Jedrychowski MP, Paulo JA, Gygi SP, Griffin PR, Nomura DK, Spiegelman BM. The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria. Cell. 2016 Jul 14;166(2):424-435. doi: 10.1016/j.cell.2016.05.071. Epub 2016 Jun 30. PMID: 27374330; PMCID: PMC4947008.