Primary Information |
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| BoMiProt ID | Bomi7441 |
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| Protein Name | Neurofilament medium polypeptide/160 kDa neurofilament protein/Neurofilament 3/Neurofilament triplet M protein |
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| Organism | Bos taurus |
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| Uniprot ID | O77788 |
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| Milk Fraction | Whey |
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| Aminoacid Length | 926 |
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| Molecular Weight | 103210 |
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| FASTA Sequence |
Download |
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| Gene Name | NEFM/NEF3/NFM |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | formation of interfilament cross-links |
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| PTMs | Acetylation, Glycosylation, Methylation, Phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|O77788|NFM_BOVIN Neurofilament medium polypeptide OS=Bos taurus OX=9913 GN=NEFM PE=1 SV=3
MSYTLDSLGNPSAYRRVTETRSSFSRISGS*30PSSGFRSQSWSRGSPST*47VSSSYKRSALAPR
LTYSSAMLSSAESSLDFSQSSSLLDGGSGPGGDYKLSRS*99NEKEQIQGLNDRFAGYIEKVH
YLEQQNKEIEAEIQALRQKQASHAQLGDAYDQEIRELRATLEMVNHEKAQVQLDSDHLEE
DIHRLKERFEEEARLRDDTEAAIRALRKDIEESSLVKVELDKKVQS*226LQDEVAFLRSNHEE
EVADLLAQIQASHITVERKDYLKTDISTALKEIRSQLESHSDQNMHQAEEWFKCRYAKLT
EAAEQNKEAIRSAKEEIAEY*320RRQLQSKSIELESVRGTKESLERQLS*346DIEERHNHDLSSYQ
DTIQQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGS*418IT
GPLYTHRQPS*430IAISSKIQKTKVEAPKLKVQHKFVEEIIEETKVEDEKS*468EMEEALTAITEE
LAVS*484VKEEVKEEEAEEKEEKEEAEEEVVAAKKS*513PVKATAPELKEEEGEKEEEEGQEEEEE
EEEAAKS*547DQAEEGGS*555EKEGS*560S*561EKEEGEQEEEGET*574EAEGEGEEAAAEAKEEKKMEEKAEEVAPKEELAAEAKVEKPEKAKSPVAKSPTT*628KS*630PTAKS*635PEAKS*640PEAKSPT*647AKS*650PTAKS*655PVAKSPTAKS*665PEAKS*670PEAKSPT*677AKS*680PTAKS*685PAAKS*690PAPKS*695PVEEVKPKAEAGAEKGEQKEKVEEEKKEAKES*727PKEEKAEKKEEKPKDVPEKKKAES*757PVKAESPVKEEVPAKPVKVS*771PEKEAKEEEKPQEKEKEKEKVEEVGGKEEGGLKESRKEDIAINGEVEGKEEEQETKEKGS*831GGEEEKGVVTNGLDVS*847PGDEKKGGDKSEEKVVVTKMVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKVEKVTSHAIVKEVTQSD
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| Predicted Disorder Regions | 480-583, 622-630, 650-662, 680-687, 770-775, 809-846 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | Phosphorylated on a number of serine residues in the repeated K-S-P tripeptide motif. |
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| Bibliography | Martínez-Morillo E, Childs C, García BP, Álvarez Menéndez FV, Romaschin AD, Cervellin G, Lippi G, Diamandis EP. Neurofilament medium polypeptide (NFM) protein concentration is increased in CSF and serum samples from patients with brain injury. Clin Chem Lab Med. 2015 Sep 1;53(10):1575-84. doi: 10.1515/cclm-2014-0908. PMID: 25720124. |
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