Primary Information |
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| BoMiProt ID | Bomi7438 |
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| Protein Name | Neuroendocrine convertase 2/NEC 2/Prohormone convertase 2/Proprotein convertase 2/PC2 |
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| Organism | Bos taurus |
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| Uniprot ID | Q9GLR0 |
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| Milk Fraction | whey |
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| Ref Sequence ID | NP_776838.1 |
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| Aminoacid Length | 638 |
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| Molecular Weight | 70247 |
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| FASTA Sequence |
Download |
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| Gene Name | PCSK2 |
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| Gene ID | 281968 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells |
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| Significance in milk | stimulating feed intake of dairy cows during early lactation |
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| PTMs | Glycosylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q9GLR0|NEC2_BOVIN Neuroendocrine convertase 2 OS=Bos taurus OX=9913 GN=PCSK2 PE=2 SV=1
MRGGCISQGKAAAGLLFCVMVFASAERPVFTNHFLVELHRGGEEKARQVAAEHGFGVRKL
PFAEGLYHFYHNGLAKARRRRSLQHQQQLERDPRVKRALQQEGFNRKKRGYRDINEIDIN
VNDPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASN
YNAEASYDFSSNDPYPYPRYTDDWSNSHGTRCAGEVSAAANNNICGVGVAYGSKVAGIRM
LDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGK
GSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRK
RNPEAGVATTDLYGN*375CTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRN
QLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQNPEKIP
TTGKPVLTLTTDACEGKENFVRYLEHVQAVVTVN*514ATRRGDLNIN*524MTSPMGTKSILLSRRP
RGDDAKVGFDKWPFMTTHTWGEDARGTWILELGFVGSAPQKGVLMEWTLMLHGTQSAPYI
DQVVRDYQSKLAMSKKEELEEELDEAVQRSLKSILGKD
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| Predicted Disorder Regions | 186-200, 272-284, 353-368, 424-426, 478-482, 631-635 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | Hwang, S. R., Ng, S. M., Steineckert, B., Seidah, N. G., & Hook, V. Y. (2000). Molecular cloning demonstrates structural features of homologous bovine prohormone convertases 1 and 2. DNA and cell biology, 19(7), 409–419. https://doi.org/10.1089/10445490050085906 |
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