Primary Information |
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| BoMiProt ID | Bomi7380 |
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| Protein Name | Nascent polypeptide-associated complex subunit alpha/Alpha-NAC |
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| Organism | Bos taurus |
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| Uniprot ID | Q5E9A1 |
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| Milk Fraction | Exosomes |
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| Ref Sequence ID | NP_001014916.1 |
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| Aminoacid Length | 215 |
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| Molecular Weight | 23370 |
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| FASTA Sequence |
Download |
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| Gene Name | NACA |
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| Gene ID | 513312 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | vertebral column |
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| Protein Function | Nascent polypeptide-associated complex (NAC) protein, a heterodimeric complex of alpha- and beta-subunits, prevents mistargeting of nascent polypeptide chains to the endoplasmic reticulum membranes. |
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| Biochemical Properties | alpha-NAC has sequence similarities with transcription-regulating proteins and has been reported to function as a transcriptional coactivator potentiating c-Jun-mediated transcription. |
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| PTMs | N6-acetylation at Lysine, Isopeptide bond formation, Phosphorylation at Ser/Thr, Ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q5E9A1|NACA_BOVIN Nascent polypeptide-associated complex subunit alpha OS=Bos taurus OX=9913 GN=NACA PE=1 SV=1
MPGEATDTVPATEQELPQPQAETGSGTESDSDESVPELEEQDS*43TQATTQQAQLAAAAEID
EEPVSKAKQSRSEKKARKAMSKLGLRQVTGVTRVTIRKSKNILFVITKPDVYKSPASDTY
IVFGEAKIEDLS*132QQAQLAAAEKFKVQGEAVSNIQENTQT*159PT*161VQEES*166EEEEVDETGVEVKDIELVMS*186QANVS*191RAKAVRALKNNS*203NDIVNAIMELTM
|
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| Predicted Disorder Regions | 1-83, 137-179 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | Phosphorylation of Ser-43 by ILK during cell adhesion may promote nuclear localization. Phosphorylation of Thr-159 by GSK3B may promote proteasome mediated degradation. |
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| Bibliography | 1.Kim SH, Shim KS, Lubec G. Human brain nascent polypeptide-associated complex alpha subunit is decreased in patients with Alzheimer' s disease and Down syndrome. J Investig Med. 2002 Jul;50(4):293-301. doi: 10.2310/6650.2002.33287. PMID: 12109594. |
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