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Primary Information | |
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| BoMiProt ID | Bomi7370 |
| Protein Name | NADH-ubiquinone oxidoreductase chain 5/NADH dehydrogenase subunit 5 |
| Organism | Bos taurus |
| Uniprot ID | P03920 |
| Milk Fraction | Whey,MFGM |
| Aminoacid Length | 606 |
| Molecular Weight | 68286 |
| FASTA Sequence | Download |
| Gene Name | MT-ND5/NADH5/ ND5 |
| Protein Existence Status | reviewed |
Secondary Information | |
| Protein Function | Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I).Participate in oxidative phosphorylation. |
| Biochemical Properties | couples the oxidation of NADH for the reduction of ubiquinone with the generation of a proton gradient that can be used for the synthesis of ATP. |
| PTMs | Formylation |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | NA |
| SCOP | Class : All alpha proteins Fold : Antiporter subunits half-channel-like Superfamily : Antiporter subunits half-channel-like Family : n/a Domain Name : 5LC5 L:113-268 Class : All alpha proteins Fold : Antiporter subunits half-channel-like Superfamily : Antiporter subunits half-channel-like Family : ND5 antiporter-like subunits Domain Name : 5LC5 L:2-605 |
| CATH | Matched CATH superfamily n/a |
| Predicted Disorder Regions | NA |
| DisProt Annotation | |
| TM Helix Prediction | 14TMHs; (9-27), (34-56), (85-107), (120-138), (142-160), (172-190), (243-265), (272-294), (313-335), (366-388), (407-429), (450-468), (480-502), (586-604) |
| PDB ID | 5LC5,5LDW,5LDX,5O31, |
| Additional Comments | Leber's hereditary optic neuropathy is the result of this gene mutation.MT-ND5 gene variation was significantly associated with brain mitochondrial respiratory function in Tibet chicken embryos under hypoxia. This identifies MT-ND5 as a candidate gene for adaptation to hypoxia (or high hatchability under hypoxia) |
| Bibliography | 1.Bao HG, Zhao CJ, Li JY, Wu Ch. Association of MT-ND5 gene variation with mitochondrial respiratory control ratio and NADH dehydrogenase activity in Tibet chicken embryos. Anim Genet. 2007 Oct;38(5):514-6. doi: 10.1111/j.1365-2052.2007.01622.x. Epub 2007 Jul 5. PMID: 17614984. 2.Seong MW, Choi J, Park SS, Kim JY, Hwang JM. Novel MT-ND5 gene mutation identified in Leber's hereditary optic neuropathy patient using mitochondrial genome sequencing. J Neurol Sci. 2017 Apr 15;375:301-303. doi: 10.1016/j.jns.2017.01.064. Epub 2017 Jan 24. PMID: 28320155. |