Search by BoMiProt ID - Bomi7368

Primary Information

BoMiProt ID Bomi7368
Protein Name NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial/Complex I-75kD/CI-75kD
Organism Bos taurus
Uniprot IDP15690
Milk FractionWhey,MFGM
Ref Sequence ID NP_777245.1
Aminoacid Length 727
Molecular Weight 79442
FASTA Sequence Download
Gene Name NDUFS1
Gene ID 288380
Protein Existence Status reviewed

Secondary Information

Protein Function This is important for energy metabolism because it is the initial enzyme of the mitochondrial respiratory chain. Reduction of the 75kDa subunit may lead to the impairment of energy metabolism and result in neuronal cell death (apoptosis), a hallmark of both neurodegenerative disorders Down syndrome (DS) and Alzheimer's disease (AD).
PTMs Acetylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
CATH Matched CATH superfamily
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments NADH: ubiquinone oxidoreductase (complex I) appears to consist of 41 subunits including 7 subunits encoded in the mitochondrial DNA (mtDNA) and 34 subunits encoded in nuclear DNA (nDNA)
Bibliography Kim SH, Vlkolinsky R, Cairns N, Fountoulakis M, Lubec G. The reduction of NADH ubiquinone oxidoreductase 24- and 75-kDa subunits in brains of patients with Down syndrome and Alzheimer's disease. Life Sci. 2001 May 4;68(24):2741-50. doi: 10.1016/s0024-3205(01)01074-8. PMID: 11400916.