Search by BoMiProt ID - Bomi7367

Primary Information

BoMiProt ID Bomi7367
Protein Name NADH-cytochrome b5 reductase 1
Organism Bos taurus
Uniprot IDQ3MHW9
Milk FractionExosomes,MFGM
Ref Sequence ID NP_001029690.1
Aminoacid Length 305
Molecular Weight 33861
FASTA Sequence Download
Gene Name CYB5R1
Gene ID 516287
Protein Existence Status Reviewed

Secondary Information

Protein Function NADH-cytochrome b5 reductase is capable of reducing different types of electron acceptors: natural, seminatural, and artifical (xenobiotic) substrates.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction 1TMH; (7-29)
Additional Comments Recessive congenital methemoglobinemia (RCM) is due to the homozygous deficiency of NADH-cytochrome b5 reductase.
Bibliography 1.Lostanlen D, Lenoir G, Kaplan JC. NADH cytochrome b5 reductase activity in lymphoid cell lines. Expression of the defect in epstein Barr virus transformed lymphoblastoid cell lines from patients with recessive congenital methemoglobinemia. J Clin Invest. 1981 Jul;68(1):279-85. doi: 10.1172/jci110244. PMID: 6265499; PMCID: PMC370795.