Primary Information |
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| BoMiProt ID | Bomi7367 |
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| Protein Name | NADH-cytochrome b5 reductase 1 |
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| Organism | Bos taurus |
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| Uniprot ID | Q3MHW9 |
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| Milk Fraction | Exosomes,MFGM |
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| Ref Sequence ID | NP_001029690.1 |
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| Aminoacid Length | 305 |
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| Molecular Weight | 33861 |
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| FASTA Sequence |
Download |
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| Gene Name | CYB5R1 |
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| Gene ID | 516287 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Protein Function | NADH-cytochrome b5 reductase is capable of reducing different types of electron acceptors: natural, seminatural, and artifical (xenobiotic) substrates. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | 1TMH; (7-29) |
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| Additional Comments | Recessive congenital methemoglobinemia (RCM) is due to the homozygous deficiency of NADH-cytochrome b5 reductase. |
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| Bibliography | 1.Lostanlen D, Lenoir G, Kaplan JC. NADH cytochrome b5 reductase activity in lymphoid cell lines. Expression of the defect in epstein Barr virus transformed lymphoblastoid cell lines from patients with recessive congenital methemoglobinemia. J Clin Invest. 1981 Jul;68(1):279-85. doi: 10.1172/jci110244. PMID: 6265499; PMCID: PMC370795. |
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