Primary Information |
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| BoMiProt ID | Bomi7363 |
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| Protein Name | NAD-dependent protein deacylase sirtuin-5, mitochondrial/Regulatory protein SIR2 homolog 5/SIR2-like protein 5 |
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| Organism | Bos taurus |
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| Uniprot ID | Q3ZBQ0 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001029467.1 |
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| Aminoacid Length | 310 |
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| Molecular Weight | 33988 |
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| FASTA Sequence |
Download |
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| Gene Name | SIRT5 |
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| Gene ID | 507347 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | primarily in the mitochondrial matrix, NAD+-dependent protein deacylases/ADP-ribosyltransferases and catalyzes the removal of negatively charged lysine acyl modifications; succinyl, malonyl, and glutaryl groups.SIRT5 mediated desuccinylation is imp for maintaining cardiac energy metabolism.promotes the activity of GAPDH and perhaps other glycolytic enzymes via demalonylation.desuccinylates PKM2 at lysine 311 to increase pyruvate kinase activity |
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| Biochemical Properties | The N-terminus contains a 36 amino acid canonical mitochondrial localization signal (MLS) and an additional stretch of 72 aa , is present in isoforms 1, 2 and 3, but absent in isoform 4.Consume nicotinamide adenine dinucleotide (NAD+) as a co-substrate, and generate the sirtuin feedback inhibitor nicotinamide (NAM), 2’-O-acyl (succinyl/malonyl/glutaryl)-ADP-ribose, and a deacylated substrate. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | Sirt5 KO mice display reduced glycolytic flux |
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| Bibliography | Kumar S, Lombard DB. Functions of the sirtuin deacylase SIRT5 in normal physiology and pathobiology. Crit Rev Biochem Mol Biol. 2018 Jun;53(3):311-334. doi: 10.1080/10409238.2018.1458071. Epub 2018 Apr 11. PMID: 29637793; PMCID: PMC6233320. |
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