Search by BoMiProt ID - Bomi7356

Primary Information

BoMiProt ID Bomi7356
Protein Name NAD(P) transhydrogenase, mitochondrial/Nicotinamide nucleotide transhydrogenase/Pyridine nucleotide transhydrogenase
Organism Bos taurus
Uniprot IDP11024
Milk FractionWhey
Ref Sequence ID NP_776368.1
Aminoacid Length 1086
Molecular Weight 113854
FASTA Sequence Download
Gene Name NNT
Gene ID 280878
Protein Existence Status reviewed

Secondary Information

Protein Function links redox states of the mitochondrial NAD(H) and NADP(H) via a reaction coupled to proton-motive force across the inner mitochondrial membrane.catalyzes an energy-linked reaction in the mitochondrial matrix that comprises a hydride transfer between NAD(H) and NADP(H) via a mechanism coupled to transmembrane H+ transport. positiverole in mitochondrial peroxide detoxification systems.
PTMs Acetylation on Lys
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
SCOP Class : Alpha and beta proteins (a/b)
Fold : DHS-like NAD/FAD-binding domain
Superfamily : DHS-like NAD/FAD-binding domain
Family : Transhydrogenase domain III (dIII)
Domain Name : 1D4O A:5-181

CATH Matched CATH superfamily
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction 12TMHs; (476-498), (505-523), (559-577), (595-617), (621-639), (646- 664), (673-691), (702-724), (743-761), (779-797), (816-838),& (858-880)
Bibliography Francisco A, Engel DF, Figueira TR, Rogério F, de Bem AF, Castilho RF. Mitochondrial NAD(P)+ Transhydrogenase is Unevenly Distributed in Different Brain Regions, and its Loss Causes Depressive-like Behavior and Motor Dysfunction in Mice. Neuroscience. 2020 Aug 1;440:210-229. doi: 10.1016/j.neuroscience.2020.05.042. Epub 2020 Jun 1. PMID: 32497756.