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Primary Information | |
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| BoMiProt ID | Bomi7356 |
| Protein Name | NAD(P) transhydrogenase, mitochondrial/Nicotinamide nucleotide transhydrogenase/Pyridine nucleotide transhydrogenase |
| Organism | Bos taurus |
| Uniprot ID | P11024 |
| Milk Fraction | Whey |
| Ref Sequence ID | NP_776368.1 |
| Aminoacid Length | 1086 |
| Molecular Weight | 113854 |
| FASTA Sequence | Download |
| Gene Name | NNT |
| Gene ID | 280878 |
| Protein Existence Status | reviewed |
Secondary Information | |
| Protein Function | links redox states of the mitochondrial NAD(H) and NADP(H) via a reaction coupled to proton-motive force across the inner mitochondrial membrane.catalyzes an energy-linked reaction in the mitochondrial matrix that comprises a hydride transfer between NAD(H) and NADP(H) via a mechanism coupled to transmembrane H+ transport. positiverole in mitochondrial peroxide detoxification systems. |
| PTMs | Acetylation on Lys |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | NA |
| SCOP | Class : Alpha and beta proteins (a/b) Fold : DHS-like NAD/FAD-binding domain Superfamily : DHS-like NAD/FAD-binding domain Family : Transhydrogenase domain III (dIII) Domain Name : 1D4O A:5-181 |
| CATH | Matched CATH superfamily 3.40.50.1220 |
| Predicted Disorder Regions | NA |
| DisProt Annotation | |
| TM Helix Prediction | 12TMHs; (476-498), (505-523), (559-577), (595-617), (621-639), (646- 664), (673-691), (702-724), (743-761), (779-797), (816-838),& (858-880) |
| PDB ID | 1D4O, |
| Bibliography | Francisco A, Engel DF, Figueira TR, Rogério F, de Bem AF, Castilho RF. Mitochondrial NAD(P)+ Transhydrogenase is Unevenly Distributed in Different Brain Regions, and its Loss Causes Depressive-like Behavior and Motor Dysfunction in Mice. Neuroscience. 2020 Aug 1;440:210-229. doi: 10.1016/j.neuroscience.2020.05.042. Epub 2020 Jun 1. PMID: 32497756. |