Primary Information |
|---|
| BoMiProt ID | Bomi7290 |
|---|
| Protein Name | Myoneurin |
|---|
| Organism | Bos taurus |
|---|
| Uniprot ID | Q3B7N9 |
|---|
| Milk Fraction | Whey |
|---|
| Ref Sequence ID | NP_001030501.1 |
|---|
| Aminoacid Length | 581 |
|---|
| Molecular Weight | 65412 |
|---|
| FASTA Sequence |
Download |
|---|
| Gene Name | MYNN |
|---|
| Gene ID | 539376 |
|---|
| Protein Existence Status | reviewed |
|---|
Secondary Information |
|---|
| Protein Function | Myoneurin, a novel member of the BTB/POZ-zinc finger family highly expressed in human muscle and involved in both transcriptional activation and repression of various genes in a broad range of species, including mammals. |
|---|
| Biochemical Properties | This molecule, called myoneurin on the basis of its prevalent expression in the neuromuscular system, contains an amino-terminal BTB/POZ domain and eight tandemly repeated zinc-finger motifs of the C(2)H(2) type. The murine myoneurin, identified in the mouse embryo, is highly homologous to the human protein. |
|---|
| PTMs | Phosphorylation at Ser |
|---|
Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q3B7N9|MYNN_BOVIN Myoneurin OS=Bos taurus OX=9913 GN=MYNN PE=2 SV=1
MQYSHHCEHLLERLNKQREAGFLCDCTIVIGEFQFKAHRNVLASFSEYFGAIYRSTSENN
VFLDQSQVKADGFQKLLEFIYTGTLNLDSWNVKEIHQAADYLKVEEVVTKCKIKMEDFAF
IANPSSTEISSITGNIELNQQTCLLTLRDYNSREKSEVSTDLVQANPKQGALAKKSSQTK
KKKKAFNSQKTGQNKTVQYPSDILENASVELFLDANKLSTPIIEQVAQRSNSELELTSVV
ENTFPAQDIVQTVTVKRKRGKSQPNCALKEHSMSNIASVKNSYELESS*288GEELDQRYSKAK
PMCNTCGKVFSEASSLRRHMRIHKGVKPYVCHLCGKAFTQCNQLKTHVRTHTGEKPYKCE
LCDKGFAQKCQLVFHSRMHHGEEKPYKCDVCNLQFATSSNLKIHARKHSGEKPYVCDRCG
QRFAQASTLTYHVRRHTGEKPYVCDTCGKAFAVSSSLITHSRKHTGERPFICELCGNSYT
DIKNLKKHKTKVHSGADKILDSSIEDHPLNEQDSIQKSPLSETLDVKPSDVTLPLTLPLG
AEDHHLLLPVADSQPPAPDALLRPAANGYSEPQLIFLQQLY
|
|---|
| Predicted Disorder Regions | 120-199, 214-222, 563-568 |
|---|
| DisProt Annotation | |
|---|
| TM Helix Prediction | No TM helices |
|---|
| Additional Comments | Significant level of myoneurin transcripts in human testis, ovary and placenta suggesting that this novel protein could also fulfill regulatory functions in the genital tract. |
|---|
| Bibliography | Alliel PM, Seddiqi N, Goudou D, Cifuentes-Diaz C, Romero N, Velasco E, Rieger F, Périn JP. Myoneurin, a novel member of the BTB/POZ-zinc finger family highly expressed in human muscle. Biochem Biophys Res Commun. 2000 Jun 24;273(1):385-91. doi: 10.1006/bbrc.2000.2862. PMID: 10873615. |
|---|
