Primary Information |
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| BoMiProt ID | Bomi7287 |
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| Protein Name | Myocyte-specific enhancer factor 2A |
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| Organism | Bos taurus |
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| Uniprot ID | A2VDZ3 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001077107.1 |
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| Aminoacid Length | 492 |
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| Molecular Weight | 52782 |
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| FASTA Sequence |
Download |
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| Gene Name | MEF2A |
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| Gene ID | 407231 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Protein Function | Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT]4TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes |
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| Significance in milk | bovine skeletal muscle myogenesis |
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| PTMs | Phosphorylation, acetylation, sumoylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A2VDZ3|MEF2A_BOVIN Myocyte-specific enhancer factor 2A OS=Bos taurus OX=9913 GN=MEF2A PE=2 SV=1
MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSSNKLFQYAS*59T
DMDKVLLKYTEYNEPHESRTNSDIVEALNKKEHRGCDS*98PDPDTSYVLTPHTEEKYKKINE
EFDNMMRNHKIAPGLPPQNFSMSVTVPVTSPSALSYTNPGSSLVSPSLAASSALADTSML
SPPQATLHRNVSPGAPQRPPSTGSAGGMLSTSDLTVPNGAGSSPVGNGFVNSRAS*235PNLIG
TTGANSLGKVMPTKS*255PPPPGGGSLGMNSRKPDLRVVIPPSSKGMMPPLNTQRISSSQATQ
PLATPVVSVTT*311PSLPPQGLVYSAMPTAYNTDYSLTSADLSALQGFNS*347PGMLSLGQVSAWQ
QHHLGQAALNSLVAGGQLSQGSNLSINTNQNINIKSEPIS*400PPRDRMT*407PSGFQQQQQPQPP
PPPPQAPQPQPRQEVGRS*438PVDSLSSSSSSYDGSDREDPRGDFHSPVVLGRPPNSEDRESP
SVKRMRMDAWVT
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| Predicted Disorder Regions | 216-221, 324-347), (369-380), (401-452), (463-475) |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | Constitutive phosphorylation on Ser-400 promotes Lys-395 sumoylation thus preventing acetylation at this site.Sumoylation on Lys-395 is enhanced by PIAS1 and represses transcriptional activity.Acetylation on Lys-395 activates transcriptional activity. Proteolytically cleaved in cerebellar granule neurons on several sites by caspase 3 and caspase 7 following neurotoxicity. |
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| Bibliography | Huang, Y., Wu, X., Guo, J., & Yuan, J. (2016). Myocyte-specific enhancer binding factor 2A expression is downregulated during temporal lobe epilepsy. The International journal of neuroscience, 126(9), 786–796. https://doi.org/10.3109/00207454.2015.1062003 |
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